PLCε signaling in cancer
- PMID: 26109147
- DOI: 10.1007/s00432-015-1999-x
PLCε signaling in cancer
Abstract
Purpose: As one of the members of the PLC family, the phosphoinositide-specific phospholipase Cε (PLCε) has been shown to play pivotal roles in multiple signal pathways and control a variety of cellular functions. A number of studies have shown that aberrant regulation of PLCε was involved in various types of animal and human cancer. However, the role of PLCε in cancer remains elusive. In this review, we provide an overview of the PLCε, especially its roles in multiple signal pathways, and summarize the recent findings that highlight the roles of PLCε in carcinogenesis and cancer progression, making an avenue to provide a novel therapeutic strategy for the treatment of cancer.
Methods: A literature search mainly paying attention to the network of PLCε involved in tumorigenesis and development was performed in electronic databases.
Results: PLCε plays a key role in medicating the development and progression of human cancers with highest potency to be a target of cancer prevention and treatment.
Keywords: Cancer; EGFR; NF-κB; Phospholipase Cε; Ras; Signal pathway.
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