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Comment
. 2015 Jul;18(7):928-9.
doi: 10.1038/nn.4047.

Genetic variation links creativity to psychiatric disorders

Matthew C Keller  1 , Peter M Visscher  2
Affiliations
Comment

Genetic variation links creativity to psychiatric disorders

Matthew C Keller et al. Nat Neurosci. 2015 Jul.

Abstract

Epidemiological studies and anecdotal evidence show overlap between psychiatric disorders and creativity, but why? A new study shows that genetics are part of the explanation.

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Figures

Figure 1
Figure 1. Estimated probability of being employed in a creative job as a function of genetic risk scores
The reported effects of the BD and SCZ genetic risk scores on being in a creative job were about the same. These effects have been converted to probabilities as a function of percentiles on either genetic risk score (black line). However, there is more noise in the BD genetic risk score, because of estimation error (see text). The blue (BD) and red (SCZ) lines show what these probabilities are predicted to be if genetic risk scores could be measured without estimation error, which will be approached as GWAS sample sizes grow.
See this image and copyright information in PMC

Comment on

  • Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.
    Power RA, Steinberg S, Bjornsdottir G, Rietveld CA, Abdellaoui A, Nivard MM, Johannesson M, Galesloot TE, Hottenga JJ, Willemsen G, Cesarini D, Benjamin DJ, Magnusson PK, Ullén F, Tiemeier H, Hofman A, van Rooij FJ, Walters GB, Sigurdsson E, Thorgeirsson TE, Ingason A, Helgason A, Kong A, Kiemeney LA, Koellinger P, Boomsma DI, Gudbjartsson D, Stefansson H, Stefansson K. Power RA, et al. Nat Neurosci. 2015 Jul;18(7):953-5. doi: 10.1038/nn.4040. Epub 2015 Jun 8. Nat Neurosci. 2015. PMID: 26053403

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