doi: 10.1016/0006-291x(89)92734-4.
Apparent sequence preference in cleavage of linear B-DNA by the Cu(II):thiol system
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- PMID: 2610689
- DOI: 10.1016/0006-291x(89)92734-4
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Apparent sequence preference in cleavage of linear B-DNA by the Cu(II):thiol system
Biochem Biophys Res Commun.
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Abstract
Cleavage of a linear tyr T fragment of duplex DNA by Cu(II):thiol combinations occurs with apparent sequence preference. The sequence selectivity was unaffected by the size, chirality or substitution pattern of the monothiol partner, presumably indicating that the Cu(II):RSH system is probing some local conformational/dynamic aspect of the DNA.
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