doi: 10.1016/j.molcel.2015.06.001.
SnapShot: ADP-Ribosylation Signaling
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- PMID: 26091348
- DOI: 10.1016/j.molcel.2015.06.001
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SnapShot: ADP-Ribosylation Signaling
Mol Cell.
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Erratum in
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SnapShot: ADP-Ribosylation Signaling.Mol Cell. 2016 May 5;62(3):472. doi: 10.1016/j.molcel.2016.04.019. Epub 2016 May 5. Mol Cell. 2016. PMID: 27153542 No abstract available.
Abstract
Intracellular protein ADP-ribosylation is catalyzed by diphteria toxin-like ADP-ribosyltransferases (ARTDs, formerly PARPs) ("writers"), which use NAD(+) for the modification of different amino acids. While some ARTD members catalyze protein poly-ADP-ribosylation, most of them are mono-ADP-ribosyltransferases. ADP-ribosylation is recognized by protein domains ("readers") and reversed by different enzymes ("erasers"). ADP-ribosylation signaling regulates several key cellular processes during health and disease.
Copyright © 2015 Elsevier Inc. All rights reserved.
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