HIV reservoirs as obstacles and opportunities for an HIV cure

doi:10.1038/ni.3152

. 2015 Jun;16(6):584-9.

doi: 10.1038/ni.3152.

HIV reservoirs as obstacles and opportunities for an HIV cure

Tae-Wook Chun¹, Susan Moir¹, Anthony S Fauci¹

Affiliations

PMID: 25990814
DOI: 10.1038/ni.3152

HIV reservoirs as obstacles and opportunities for an HIV cure

Tae-Wook Chun et al. Nat Immunol. 2015 Jun.

. 2015 Jun;16(6):584-9.

doi: 10.1038/ni.3152.

Authors

Tae-Wook Chun¹, Susan Moir¹, Anthony S Fauci¹

Affiliation

¹ National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

PMID: 25990814
DOI: 10.1038/ni.3152

Abstract

The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is discontinued, even if plasma viremia has been successfully suppressed for prolonged periods of time. Numerous approaches aimed at eradicating the virus, as well as maintaining its prolonged suppression in the absence of ART, have had little success. A better understanding of the pathophysiologic nature of HIV reservoirs and the impact of various interventions on their persistence is essential for the development of successful therapeutic strategies against HIV or the long-term control of infection. Here, we discuss the persistent HIV reservoir as a barrier to cure as well as the current therapeutic strategies aimed at eliminating or controlling the virus in the absence of ART.

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[1] Nat Med. 2009 Aug;15(8):893-900 - PubMed

[2] Nat Med. 2009 Aug;15(8):893-900 - PubMed

[3] Sci Transl Med. 2011 Apr 20;3(79):79ps13 - PubMed

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HIV reservoirs as obstacles and opportunities for an HIV cure

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HIV reservoirs as obstacles and opportunities for an HIV cure

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