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. 2015 Sep;181(3):417-26.
doi: 10.1111/cei.12651. Epub 2015 Jun 22.

Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus

Elisabet Svenungsson  1 , Daniel Engelbertsen  2 , Maria Wigren  2 , Johanna T Gustafsson  1 , Iva Gunnarsson  1 , Kerstin Elvin  3 , Kerstin Jensen-Urstad  4 , Gunilla Nordin Fredrikson  2 , Jan Nilsson  2
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Decreased levels of autoantibodies against apolipoprotein B-100 antigens are associated with cardiovascular disease in systemic lupus erythematosus

Elisabet Svenungsson et al. Clin Exp Immunol. 2015 Sep.

Abstract

Increased production of autoantibodies is a characteristic feature of systemic lupus erythematosus (SLE) and there is evidence that several of these autoantibodies may contribute to increased cardiovascular disease (CVD) in SLE. Autoantibodies against the apolipoprotein (apo) B-100 peptides p45 and p210 have been associated with a lower CVD risk in non-SLE cohorts. The aim of the present study was to investigate how SLE affects the occurrence of these potentially protective autoantibodies. The study cohort consisted of 434 SLE patients and 322 age- and sex-matched population controls. Antibodies against native and malondialdehyde (MDA)-modified p45 and p210 were measured by enzyme-linked immunosorbent assay (ELISA). SLE patients had significantly lower levels of p210 immunoglobulin (Ig)G and p45 IgM (both the native and malondialdehyde (MDA)-modified forms). SLE patients with manifest CVD (myocardial infarction, ischaemic cerebrovascular disease or peripheral vascular disease) had lower levels p210 IgG and p45 IgM than SLE patients without CVD. Decreased levels of these autoantibodies were also observed in SLE patients with permanent organ damage, as assessed by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) Damage Index (SDI). The present findings show that patients with SLE, a condition generally characterized by abundance of autoantibodies of multiple specificities, have reduced levels of antibodies against the apo B-100 antigens p45 and p210 and that the levels of these antibodies are reduced further in SLE patients with CVD. These observations suggest the possibility that an impaired antibody-mediated removal of damaged LDL particles may contribute to the development of vascular complications and organ damage in SLE.

Keywords: antibodies; human; systemic lupus erythematosus.

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Figures

Fig. 1
Fig. 1
One-dimensional box-plots showing median and 95% confidence interval for p45 immunoglobulin (Ig)M, malondialdehyde (MDA)-p45 IgM, p210 IgG and MDA-p210 IgG in systemic lupus erythematosus (SLE) patients with and without cardiovascular disease (CVD).
See this image and copyright information in PMC

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References

    1. Esdaile JM, Abrahamowicz M, Grodzicky T, et al. Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus. Arthritis Rheum. 2001;44:2331–7. - PubMed
    1. Rahman P, Urowitz MB, Gladman DD, Bruce IN, Genest J., Jr Contribution of traditional risk factors to coronary artery disease in patients with systemic lupus erythematosus. J Rheumatol. 1999;26:2363–8. - PubMed
    1. Manzi S, Selzer F, Sutton-Tyrrell K, et al. Prevalence and risk factors of carotid plaque in women with systemic lupus erythematosus. Arthritis Rheum. 1999;42:51–60. - PubMed
    1. Bengtsson C, Ohman ML, Nived O, Dahlqvist SR. Cardiovascular event in systemic lupus erythematosus in northern Sweden: incidence and predictors in a 7-year follow-up study. Lupus. 2012;21:452–9. - PubMed
    1. Magder LS, Petri M. Incidence of and risk factors for adverse cardiovascular events among patients with systemic lupus erythematosus. Am J Epidemiol. 2012;176:708–19. - PMC - PubMed

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