Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jun;15(6):604.
doi: 10.1007/s11892-015-0604-7.

Does nutrient sensing determine how we "see" food?

Sophie C Hamr  1 , Beini Wang, Timothy D Swartz, Frank A Duca
Affiliations
Review

Does nutrient sensing determine how we "see" food?

Sophie C Hamr et al. Curr Diab Rep. 2015 Jun.

Abstract

The ability to "see" both incoming and circulating nutrients plays an essential role in the maintenance of energy homeostasis. As such, nutrient-sensing mechanisms in both the gastrointestinal tract and the brain have been implicated in the regulation of energy intake and glucose homeostasis. The intestinal wall is able to differentiate individual nutrients through sensory machinery expressed in the mucosa and provide feedback signals, via local gut peptide action, to maintain energy balance. Furthermore, both the hypothalamus and hindbrain detect circulating nutrients and respond by controlling energy intake and glucose levels. Conversely, nutrient sensing in the intestine plays a role in stimulating food intake and preferences. In this review, we highlight the emerging evidence for the regulation of energy balance through nutrient-sensing mechanisms in the intestine and the brain, and how disruption of these pathways could result in the development of obesity and type 2 diabetes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Diabetes. 2002 Feb;51(2):271-5 - PubMed
    1. Diabetes. 1995 Feb;44(2):180-4 - PubMed
    1. Physiol Behav. 2014 Apr 22;129:64-72 - PubMed
    1. PLoS One. 2011;6(9):e24992 - PubMed
    1. Trends Endocrinol Metab. 2001 May-Jun;12 (4):169-73 - PubMed

Publication types

LinkOut - more resources