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. 2014 Jul 3;3(7):e947872.
doi: 10.4161/21624011.2014.947872. eCollection 2014.

Healing after death: antitumor immunity induced by oncolytic adenoviral therapy

Hong Jiang  1 , Juan Fueyo  1
Affiliations

Healing after death: antitumor immunity induced by oncolytic adenoviral therapy

Hong Jiang et al. Oncoimmunology. .

Abstract

We recently evaluated the capacity of Delta-24-RGD oncolytic adenovirus to trigger an antitumor immune response in a syngeneic mouse glioma model. This virotherapy elicited immunity against both tumor-associated antigens and viral antigens. An immunogenic cell death accompanied by pathogen- or damage- associated patterns (PAMPs and DAMPs) induced by the virus may be responsible for the adenoviral-mediated antitumor effect.

Keywords: antitumor immunity; danger (or damage)-associated molecular patterns (DAMPs); immunogenic cell death; oncolytic adenovirus; pathogen-associated patterns (PAMPs).

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Figures

Figure 1.
Figure 1.
Delta-24-RGD elicits antitumor immunity during adenoviral-mediated cancer therapy. Adenoviral infection of the tumor cells increases the activity of proteasome and the presentation of tumor-associate antigens (TAAs) to T cells. Adenovirus also induces autophagic cell death which is immunogenic (immunogenic cell death, ICD), resulting in the release of DAMPs and TAAs. DAMPs, together with PAMPs from the viral infection, stimulate innate immune response and the presentation of TAAs to T cells by activated immune cells. Thus, adaptive immunity against tumor is instigated.
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