Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May;53(4):2124-31.
doi: 10.1007/s12035-015-9181-7. Epub 2015 May 2.

Experimental Advances Towards Neural Regeneration from Induced Stem Cells to Direct In Vivo Reprogramming

Sara Dametti  1 , Irene Faravelli  1 , Margherita Ruggieri  1 , Agnese Ramirez  1 , Monica Nizzardo  1 , Stefania Corti  2
Affiliations
Review

Experimental Advances Towards Neural Regeneration from Induced Stem Cells to Direct In Vivo Reprogramming

Sara Dametti et al. Mol Neurobiol. 2016 May.

Abstract

Neuronal loss is a common substrate of many neurological diseases that still lack effective treatments and highly burden lives of affected individuals. The discovery of self-renewing stem cells within the central nervous system (CNS) has opened the doors to the possibility of using the plasticity of CNS as a potential strategy for the development of regenerative therapies after injuries. The role of neural progenitor cells appears to be crucial, but insufficient in reparative processes after damage. In addition, the mechanisms that regulate these events are still largely unknown. Stem cell-based therapeutic approaches have primarily focused on the use of either induced pluripotent stem cells or induced neural stem cells as sources for cell transplantation. More recently, in vivo direct reprogramming of endogenous CNS cells into multipotent neural stem/progenitor cells has been proposed as an alternative strategy that could overcome the limits connected with both the invasiveness of exogenous cell transplantation and the technical issues of in vitro reprogramming (i.e., the time requested and the limited available amount of directly induced neuronal cells). In this review, we aim to highlight the recent studies on in vivo direct reprogramming, focusing on astrocytes conversion to neurons or to neural stem/precursors cells, in the perspective of future therapeutic purposes for neurological disorders.

Keywords: In vivo reprogramming; Neural stem cells; Neuronal loss; Regeneration.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Cell Stem Cell. 2014 Feb 6;14(2):188-202 - PubMed
    1. J Neurosci. 2007 Aug 8;27(32):8654-64 - PubMed
    1. Nat Biotechnol. 2009 Aug;27(8):743-5 - PubMed
    1. Cell Death Differ. 2012 May;19(5):779-87 - PubMed
    1. Nat Neurosci. 2002 Apr;5(4):308-15 - PubMed

Publication types

LinkOut - more resources