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Review
. 2015:2015:461524.
doi: 10.1155/2015/461524. Epub 2015 Mar 22.

Evolution of genetic techniques: past, present, and beyond

Asude Alpman Durmaz  1 , Emin Karaca  1 , Urszula Demkow  2 , Gokce Toruner  3 , Jacqueline Schoumans  4 , Ozgur Cogulu  1
Affiliations
Review

Evolution of genetic techniques: past, present, and beyond

Asude Alpman Durmaz et al. Biomed Res Int. 2015.

Abstract

Genetics is the study of heredity, which means the study of genes and factors related to all aspects of genes. The scientific history of genetics began with the works of Gregor Mendel in the mid-19th century. Prior to Mendel, genetics was primarily theoretical whilst, after Mendel, the science of genetics was broadened to include experimental genetics. Developments in all fields of genetics and genetic technology in the first half of the 20th century provided a basis for the later developments. In the second half of the 20th century, the molecular background of genetics has become more understandable. Rapid technological advancements, followed by the completion of Human Genome Project, have contributed a great deal to the knowledge of genetic factors and their impact on human life and diseases. Currently, more than 1800 disease genes have been identified, more than 2000 genetic tests have become available, and in conjunction with this at least 350 biotechnology-based products have been released onto the market. Novel technologies, particularly next generation sequencing, have dramatically accelerated the pace of biological research, while at the same time increasing expectations. In this paper, a brief summary of genetic history with short explanations of most popular genetic techniques is given.

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Figure 1
Figure 1
Landmarks in the history of genetics.
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References

    1. Stewart G. B. The Kid Haven Science Library: “Microscopes”. Farmington Hills, Mich, USA: Kid Heaven Press; 2003.
    1. Hooke R. Micrographia: Or, Some Physiological Descriptions of Minute Bodies Made by Magnifying Glasses. London, UK: 1665. (edited by J. Martyn and J. Allestry).
    1. Archiv für mikroskopische Anatomie und Entwicklungsmechanik. 1888;32
    1. Watson J. D., Crick F. H. The structure of DNA. Cold Spring Harbor Symposia on Quantitative Biology. 1953;18:123–131. doi: 10.1101/sqb.1953.018.01.020. - DOI - PubMed
    1. Tjio J. H., Levan A. The chromosome number of man. Hereditas. 1956;42:1–6.

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