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Review
. 2015 Apr 13;13(4):2158-82.
doi: 10.3390/md13042158.

The potential of chitosan and its derivatives in prevention and treatment of age-related diseases

Garry Kerch  1
Affiliations
Review

The potential of chitosan and its derivatives in prevention and treatment of age-related diseases

Garry Kerch. Mar Drugs. .

Abstract

Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.

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Figures

Figure 1
Figure 1
The potential effect of chitosan on age-related dysfunctions.
Figure 2
Figure 2
The possible anticancer effect of chitosan and polyphenols encapsulated in chitosan nanoparticles.
Figure 3
Figure 3
The possible effect of chitosan oligosaccharide on Alzheimer disease pathology.
Figure 4
Figure 4
The possible influence of chitosan on low density lipoprotein cholesterol content, hydration, protein conformation, and protein conformational diseases.
See this image and copyright information in PMC

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