Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

doi:10.1016/j.cmet.2015.03.002

Review

. 2015 Apr 7;21(4):517-26.

doi: 10.1016/j.cmet.2015.03.002.

Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

Fabiola Bovenga¹, Carlo Sabbà², Antonio Moschetta³

Affiliations

¹ Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy; National Cancer Institute, IRCCS Istituto Oncologico Giovanni Paolo II, 70124 Bari, Italy.
² Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy.
³ Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy; National Cancer Institute, IRCCS Istituto Oncologico Giovanni Paolo II, 70124 Bari, Italy. Electronic address: antonio.moschetta@uniba.it.

PMID: 25863245
DOI: 10.1016/j.cmet.2015.03.002

Free article

Review

Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

Fabiola Bovenga et al. Cell Metab. 2015.

Free article

. 2015 Apr 7;21(4):517-26.

doi: 10.1016/j.cmet.2015.03.002.

Authors

Fabiola Bovenga¹, Carlo Sabbà², Antonio Moschetta³

Affiliations

¹ Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy; National Cancer Institute, IRCCS Istituto Oncologico Giovanni Paolo II, 70124 Bari, Italy.
² Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy.
³ Clinica Medica Cesare Frugoni, Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, 70124 Bari, Italy; National Cancer Institute, IRCCS Istituto Oncologico Giovanni Paolo II, 70124 Bari, Italy. Electronic address: antonio.moschetta@uniba.it.

PMID: 25863245
DOI: 10.1016/j.cmet.2015.03.002

Abstract

Liver X receptors (LXRs) are members of the nuclear receptor superfamily of DNA-binding transcription factors and act as sensors of cholesterol homeostasis. Under normal conditions, when intracellular cholesterol concentration increases, cells synthesize oxysterols and activate the LXR transcriptional network to drive cholesterol efflux and reduce cholesterol influx and synthesis. During normal and cancer cell proliferation, there is a net uncoupling between intracellular cholesterol increase and LXR activation resulting from the reduced intracellular oxysterol concentration. This review dissects the novel mechanisms of a previously unrecognized metabolic uncoupling, supporting the activation of the LXR axis as a bona fide therapeutic approach in cancer.

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Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

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Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

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