Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia

doi:10.3324/haematol.2014.118570

. 2015 Jul;100(7):e254-6.

doi: 10.3324/haematol.2014.118570. Epub 2015 Mar 20.

Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia

Daisuke Araki¹, Megan Othus², Roland B Walter³, Vicky Sandhu⁴, Brenda M Sandmaier⁵, Pamela S Becker³, Frederick R Appelbaum⁵, Elihu H Estey⁶

Affiliations

¹ Department of Medicine, University of Washington, Seattle, WA, USA.
² Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
³ Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
⁴ Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
⁵ Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA.
⁶ Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA eestey@uw.edu.

PMID: 25795719
PMCID: PMC4486235
DOI: 10.3324/haematol.2014.118570

Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia

Daisuke Araki et al. Haematologica. 2015 Jul.

. 2015 Jul;100(7):e254-6.

doi: 10.3324/haematol.2014.118570. Epub 2015 Mar 20.

Authors

Daisuke Araki¹, Megan Othus², Roland B Walter³, Vicky Sandhu⁴, Brenda M Sandmaier⁵, Pamela S Becker³, Frederick R Appelbaum⁵, Elihu H Estey⁶

Affiliations

¹ Department of Medicine, University of Washington, Seattle, WA, USA.
² Public Health Sciences Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
³ Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
⁴ Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.
⁵ Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA Department of Medicine, Division of Oncology, University of Washington, Seattle, WA, USA.
⁶ Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA eestey@uw.edu.

PMID: 25795719
PMCID: PMC4486235
DOI: 10.3324/haematol.2014.118570

No abstract available

Keywords: 1st CR duration; prior allogeneic transplant; relapsed AML.

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Figures

**Figure 1.**
Overall survival after first salvage therapy, stratified by HCT status in CR1. No-HCT (n=116, black line), myeloablative HCT (n=26, red line), and reduced intensity HCT (n=19, green line). Log rank P=0.86.

See this image and copyright information in PMC

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References

1. Koreth J, Schlenk R, Kopecky KJ, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA. 2009;301(22):2349–2361. - PMC - PubMed
1. Appelbaum FR, Pearce SF. Hematopoietic cell transplantation in first complete remission versus early relapse. Best Pract Res Clin Haematol. 2006;19(2):333–339. - PubMed
1. Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. 2005;23(9):1969–1978. - PubMed
1. Burnett A, Goldstone A, Hills R, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31(10):1293–1301. - PubMed
1. Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453–474. - PubMed

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[1] Koreth J, Schlenk R, Kopecky KJ, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA. 2009;301(22):2349–2361. - PMC - PubMed

[2] Koreth J, Schlenk R, Kopecky KJ, et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials. JAMA. 2009;301(22):2349–2361. - PMC - PubMed

[3] Appelbaum FR, Pearce SF. Hematopoietic cell transplantation in first complete remission versus early relapse. Best Pract Res Clin Haematol. 2006;19(2):333–339. - PubMed

[4] Appelbaum FR, Pearce SF. Hematopoietic cell transplantation in first complete remission versus early relapse. Best Pract Res Clin Haematol. 2006;19(2):333–339. - PubMed

[5] Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. 2005;23(9):1969–1978. - PubMed

[6] Breems DA, Van Putten WL, Huijgens PC, et al. Prognostic index for adult patients with acute myeloid leukemia in first relapse. J Clin Oncol. 2005;23(9):1969–1978. - PubMed

[7] Burnett A, Goldstone A, Hills R, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31(10):1293–1301. - PubMed

[8] Burnett A, Goldstone A, Hills R, et al. Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission. J Clin Oncol. 2013;31(10):1293–1301. - PubMed

[9] Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453–474. - PubMed

[10] Döhner H, Estey EH, Amadori S, et al. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453–474. - PubMed

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Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia

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Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia

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