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Review
. 2015 Mar 11;17(3):295-300.
doi: 10.1016/j.chom.2015.02.012.

Influenza vaccines: challenges and solutions

Katherine Houser  1 , Kanta Subbarao  2
Affiliations
Review

Influenza vaccines: challenges and solutions

Katherine Houser et al. Cell Host Microbe. .

Abstract

Vaccination is the best method for the prevention and control of influenza. Vaccination can reduce illness and lessen severity of infection. This review focuses on how currently licensed influenza vaccines are generated in the U.S., why the biology of influenza poses vaccine challenges, and vaccine approaches on the horizon that address these challenges.

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Figures

Figure 1
Figure 1. Stages of the viral life cycle and vaccine targets
Many stages of viral infection can be targeted by vaccines; the targets of the vaccines described in this review are indicated. Vaccines that elicit an immune response that blocks a stage in the viral life cycle are shown in red, while vaccines that activate a specific host immune response are shown in green. Abbreviations: IIV: inactivated influenza vaccine; LAIV: live attenuated influenza vaccine; COBRA: computationally optimized broadly reactive antigen; HA: hemagglutinin; ADCC: antibody dependent cell cytotoxicity
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