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. 2014;5(2):e27976.
doi: 10.4161/trns.27976.

Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expression

Gap Ryol Lee  1
Affiliations

Role of YY1 in long-range chromosomal interactions regulating Th2 cytokine expression

Gap Ryol Lee. Transcription. 2014.

Abstract

The molecular mechanism for chromatin remodeling and chromosomal interactions at the Th2 cytokine locus is not fully understood. Recently, we showed that transcription factor YY1 is critically involved in these events. This article discusses the possible roles of YY1 in these processes with particular emphasis on long-range chromosomal interactions.

Keywords: Th2 cytokine locus; Th2 differentiation; YY1; chromatin remodeling; chromosomal interaction; transcription factor.

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Figure 1. A proposed model for the role of YY1 in Th2 locus regulation. YY1 recruits PcG proteins and other chromatin remodeling factors into the Th2 LCR and the promoters of Il4, Il13, and Il5 genes. Then, Th2-determining transcription factor GATA3 is recruited to the promoters and enhancers, stimulating transcriptional activity of RNA polymerase II. CTCF and cohesin bind to boundary regions of the Th2 locus and demarking it as a topological domain. These events occur on the platform of the nuclear matrix, which contains SATB1. The promoters of Th2 cytokine genes are in close spatial proximity with each other and with Th2 LCR; however, unrelated Rad50 gene is far apart from the chromatin hub.
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