Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Dec;1362(1):215-23.
doi: 10.1111/nyas.12607. Epub 2015 Feb 26.

Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model

Zhiwei Xu  1 , Laurence Morel  1
Affiliations
Review

Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model

Zhiwei Xu et al. Ann N Y Acad Sci. 2015 Dec.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of complex etiology in which B cells play a central role. An expanded number of B-1a cells have been consistently associated with murine lupus, and more recently with human SLE. We have identified Cdkn2c, a gene that controls cell cycle progression, as a key regulator of B-1a cell numbers and have associated Cdkn2c deficiency with autoimmune pathology, including the production of autoantibodies and the skewing of CD4(+) T cells toward inflammatory effector functions. We review the genetic studies that have led to these findings, as well as the possible mechanisms by which B-1a cell expansion and Cdkn2c deficiency are related to SLE pathogenesis.

Keywords: B-1a cell; NZM2410 mice; systemic lupus erythematosus.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed model for the p18 regulation of autoimmune pathogenesis in the NZM2410 model of lupus. Boxes show processes that we have observed in the experiments reviewed here. Filled arrows shown causal links established by our studies or that of others. Dashed arrows show potential causal links based on either in vitro studies and/or associations.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sang A, et al. Animal models of molecular pathology: Systemic Lupus Erythematosus. In: Conn PM, editor. Progress in Molecular Biology and Translational Science. Vol. 105. Academic Press; 2012. pp. 321–370. - PubMed
    1. Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol. 1985;37:269–390. - PubMed
    1. Wakeland EK, et al. Delineating the genetic basis of systemic lupus erythematosus. Immunity. 2001;15:397–408. - PubMed
    1. Harley IT, et al. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet. 2009;10:285–290. - PMC - PubMed
    1. Morel L. Genetics of SLE: evidence from mouse models. Nat Rev Rheumatol. 2010;6:348–357. - PubMed

Publication types

MeSH terms

Substances