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. 2014 Oct-Dec;9(4):417-22.
doi: 10.4103/2008-322X.150803.

Topical cyclosporine a for treatment of dry eye due to chronic mustard gas injury

Khosrow Jadidi  1 , Yunes Panahi  2 , Ali Ebrahimi  3 , Mostafa Mafi  4 , Farhad Nejat  2 , Amirhossein Sahebkar  5
Affiliations

Topical cyclosporine a for treatment of dry eye due to chronic mustard gas injury

Khosrow Jadidi et al. J Ophthalmic Vis Res. 2014 Oct-Dec.

Abstract

Purpose: To evaluate the efficacy of topical cyclosporine A (tCsA) for treatment of dry eye disease in patients suffering from chronic ocular complications of mustard gas (MG) injury.

Methods: This interventional case series included patients with MG injury suffering from severe dry eye despite receiving artificial tears and punctal plugs. Patients were administered tCsA 0.05% twice daily for 3 months. Severity of the condition was evaluated by measuring tear osmolarity, ocular surface disease index (OSDI), tear break-up time (TBUT), and Schirmer's test at baseline and at the end of study.

Results: A total of 34 patients with chronic MG injury and mean age of 47.1 ± 6.5 years were studied. Compared to baseline values, tear osmolarity (301.7 ± 11.5 vs. 286.3 ± 7.9 mOsmol/L, P < 0.001) and OSDI (47.5 ± 7.2 vs. 42.7 ± 7.1, P < 0.001) were significantly improved. Likewise, Schirmer's test (4.6 ± 1.3 vs. 5 ± 1.3 mm, P < 0.001) and TBUT (1.9 ± 1.4 vs. 2.7 ± 1.5 s, P < 0.001) also significantly recovered at the end of the study.

Conclusion: TCsA 0.05% reduces tear osmolarity and improves dry eye symptoms and can serve as an efficacious treatment for ocular complications in patients with chronic MG injury.

Keywords: Cyclosporine A; Dry Eye Syndrome; Mustard Gas; Tear Osmolarity.

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Conflict of interest statement

Conflict of Interest: Baqiyatallah University of Medical Sciences.

Figures

Figure 1
Figure 1
Dry eye parameters before and after treatment with topical cyclosporine A. Values are mean±standard deviation. OSDI, ocular surface disease index; TBUT, tear break-up time; LogMAR, logarithm of the minimum angle of resolution.
Figure 2
Figure 2
Proportion of subjects with improved stable or worsened score for each efficacy measure. OSDI, ocular surface disease index; TBUT, tear break-up time.
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References

    1. Solberg Y, Alcalay M, Belkin M. Ocular injury by mustard gas. Surv Ophthalmol. 1997;41:461–466. - PubMed
    1. Safarinejad MR, Moosavi SA, Montazeri B. Ocular injuries caused by mustard gas: Diagnosis, treatment, and medical defense. Mil Med. 2001;166:67–70. - PubMed
    1. Etezad-Razavi M, Mahmoudi M, Hefazi M, Balali-Mood M. Delayed ocular complications of mustard gas poisoning and the relationship with respiratory and cutaneous complications. Clin Experiment Ophthalmol. 2006;34:342–346. - PubMed
    1. Baradaran-Rafii A, Eslani M, Tseng SC. Sulfur mustard-induced ocular surface disorders. Ocul Surf. 2011;9:163–178. - PubMed
    1. Javadi MA, Yazdani S, Sajjadi H, Jadidi K, Karimian F, Einollahi B, et al. Chronic and delayed-onset mustard gas keratitis: Report of 48 patients and review of literature. Ophthalmology. 2005;112:617–625. - PubMed