Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb 2;20(2):2591-610.
doi: 10.3390/molecules20022591.

Synthesis of novel triazoles, tetrazine, thiadiazoles and their biological activities

Mohammed A Al-Omair  1 , Abdelwahed R Sayed  2   3 , Magdy M Youssef  4   5
Affiliations

Synthesis of novel triazoles, tetrazine, thiadiazoles and their biological activities

Mohammed A Al-Omair et al. Molecules. .

Abstract

An expedient synthesis of novel triazoles, tetrazine and thiadiazoles, using conveniently accessible and commercially available starting materials has been achieved. The synthesized compounds were characterized by spectroscopic and elemental analyses, and screened for their antibacterial activities against four different strains, namely E. coli, P. aeruginosa, S. aureus and B. megaterium. In particular, the compounds 5, 24 and 26h exhibited excellent antibacterial activities compared to the reference antibiotic. To get further insight about their behavior, these compounds were tested for their antioxidant activities via SOD-like activity, DPPH free radical scavenging activity, ABST and NO, which showed promising results. Furthermore, these compounds effectively promoted the cleavage of genomic DNA as well, in the absence of any external additives.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
Synthesis of 2-hydroxy-N-phenylbenzohydrazonoyl bromide 4.
Scheme 2
Scheme 2
Synthesis of triazoline derivatives 9 and 10.
Scheme 3
Scheme 3
Synthesis of triazolines 12–14 and tetrazine 15.
Scheme 4
Scheme 4
Synthesis of thiadiazoles 20 and 21.
Scheme 5
Scheme 5
Synthesis of thiadiazole 24.
Scheme 6
Scheme 6
Synthesis of dihydrazones 26.
Figure 1
Figure 1
A figure showing the degradation effect of 4 μg of series (Lanes 3–19) on the genomic DNA isolated from E. coli, Lane1 E. coli DNA and lane 2 E. coli DNA + DMSO.
Figure 2
Figure 2
Antioxidant activities of compounds using DPPH.
Figure 3
Figure 3
Antioxidant activities of compounds using ABTS.
Figure 4
Figure 4
Antioxidant activities of compounds using NO.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Liu X.H., Tan C.X., Weng J.Q. Phase transfer-catalyzed, one-pot synthesis of some novel N-pyrimidinyl-N'-nicotinylthiourea derivatives. Phosphorus Sulfur Silicon Relat. Elem. 2011;186:552–557. doi: 10.1080/10426507.2010.508059. - DOI
    1. Su N.N., Li Y., Yu S.J., Zhang X., Liu X.H., Zhao W.G. Microwave-assisted synthesis of some novel 1,2,3-triazoles by click chemistry, and their biological activity. Res. Chem. Intermed. 2013;39:759–766. doi: 10.1007/s11164-012-0595-9. - DOI
    1. Liu X.H., Pan L., Tan C.X., Weng J.Q., Wang B.L., Li Z.M. Synthesis, crystal structure, bioactivity and DFT calculation of new oxime ester derivatives containing cyclopropane moiety. Pestic. Biochem. Physiol. 2011;101:143–147. doi: 10.1016/j.pestbp.2011.08.006. - DOI
    1. Liu X.H., Pan L., Ma Y., Weng J.Q., Tan C.X., Li Y.H., Shi Y.X., Li B.J., Li Z.M., Zhang Y.G. Design, synthesis, biological activities, and 3D-QSAR of new N,N'-diacylhydrazines containing 2-(2,4-dichlorophenoxy)propane moiety. Chem. Biol. Drug Des. 2011;78:689–694. doi: 10.1111/j.1747-0285.2011.01205.x. - DOI - PubMed
    1. Chen P.Q., Tan C.X., Weng J.Q., Liu X.H. Synthesis, structure and DFT calculation of chlorimuron-ethyl. Asian J. Chem. 2012;24:2808–2810.

Publication types

MeSH terms

LinkOut - more resources