Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar 3:6:40-42.
doi: 10.4172/jaa.1000093.

Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus)

Jorge Cg Blanco  1 , Marina S Boukhvalova  1 , Daniel R Perez  2 , Stefanie N Vogel  3 , Adriana Kajon  4
Affiliations

Modeling Human Respiratory Viral Infections in the Cotton Rat (Sigmodon hispidus)

Jorge Cg Blanco et al. J Antivir Antiretrovir. .

Abstract

For over three decades, cotton rats have been a preferred model for human Respiratory Syncytial Virus (RSV) infection and pathogenesis, and a reliable model for an impressive list of human respiratory pathogens including adenoviruses, para influenza virus, measles, and human metapneumo virus. The most significant contribution of the cotton rat to biomedical research has been the development of anti-RSV antibodies for prophylactic use in high-risk infants. More recently, however, the cotton rat model has been further explored as a model for infection with other respiratory viral pathogens including influenza and rhinovirus.Together with RSV, these viruses inflict the greatest impact on the human respiratory health.This review will focus on the characteristics of these new models and their potential contribution to the development of new therapies.

Keywords: Cotton rat; Influenza; Rhinovirus; Viral infections.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Eritoran (E5564).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Prince GA, Jenson AB, Horswood RL, Camargo E, Chanock RM. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol. 1978;93:771–791. - PMC - PubMed
    1. Niewiesk S, Eisenhuth I, Fooks A, Clegg JC, Schnorr JJ, et al. Measles virus-induced immune suppression in the cotton rat (Sigmodonhispidus) model depends on viral glycoproteins. J Virol. 1997;71:7214–7219. - PMC - PubMed
    1. Wyde PR, Moore-Poveda DK, Daley NJ, Oshitani H. Replication of clinical measles virus strains in hispid cotton rats. Proc Soc Exp Biol Med. 1999;221:53–62. - PubMed
    1. Ginsberg HS, Lundholm-Beauchamp U, Horswood RL, Pernis B, Wold WS, et al. Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc Natl Acad Sci USA. 1989;86:3823–3827. - PMC - PubMed
    1. Trousdale MD, McDonnell PJ. Deletion of adenovirus type 5 early gene 3 enhances virulence of ocular disease in the cotton rat. Invest Ophthalmol Vis Sci. 1992;33:1423.

LinkOut - more resources