Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2015 Jan 27;7(1):121-6.
doi: 10.4254/wjh.v7.i1.121.

HBV and HIV co-infection: Impact on liver pathobiology and therapeutic approaches

Mohammad Khalid Parvez  1
Affiliations
Review

HBV and HIV co-infection: Impact on liver pathobiology and therapeutic approaches

Mohammad Khalid Parvez. World J Hepatol. .

Abstract

The consequences of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection on progression of severe liver diseases is a serious public health issue, worldwide. In the co-infection cases, about 90% of HIV-infected population is seropositive for HBV where approximately 5%-40% individuals are chronically infected. In HIV co-infected individuals, liver-related mortality is estimated over 17 times higher than those with HBV mono-infection. The spectrum of HIV-induced liver diseases includes hepatitis, steatohepatitis, endothelialitis, necrosis, granulomatosis, cirrhosis and carcinoma. Moreover, HIV co-infection significantly alters the natural history of hepatitis B, and therefore complicates the disease management. Though several studies have demonstrated impact of HIV proteins on hepatocyte biology, only a few data is available on interactions between HBV and HIV proteins. Thus, the clinical spectrum as well as the complexity of the co-infection offers challenging fronts to study the underlying molecular mechanisms, and to design effective therapeutic strategies.

Keywords: Chronic hepatitis B; Hepatitis B virus; Hepatitis B virus and human immunodeficiency virus co-infection; Hepatopathogenesis; Human immunodeficiency virus; Human immunodeficiency virus-hepatotropism.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A cartoon depiction of hepatitis B virus and human immunodeficiency virus co-infection of liver. Intracellular locations of the two viruses in hepatocytes, liver sinusoidal endothelial cells, Kupffer cells, portal mononuclear inflammatory cells, stellate cells, dendritic cells and Kupffer cells are shown (upper panel). The structural and genomic organizations of HIV and HBV indicating the probable trans-regulation of HBV-DNA and HBsAg by HIVgp120 (lower panel). PMIC: Portal mononuclear inflammatory cell; HIV: Human immunodeficiency virus; HBV: Hepatitis B virus; DNA: Deoxyribonucleic acid; HBsAg: Hepatitis B surface antigen; HBcAg: Hepatitis B core antigen; RT: HIV reverse-transcriptase.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Thio CL. Hepatitis B and human immunodeficiency virus coinfection. Hepatology. 2009;49:S138–S145. - PubMed
    1. Sun HY, Sheng WH, Tsai MS, Lee KY, Chang SY, Hung CC. Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: a review. World J Gastroenterol. 2014;20:14598–14614. - PMC - PubMed
    1. Thio CL, Smeaton L, Saulynas M, Hwang H, Saravanan S, Kulkarni S, Hakim J, Nyirenda M, Iqbal HS, Lalloo UG, et al. Characterization of HIV-HBV coinfection in a multinational HIV-infected cohort. AIDS. 2013;27:191–201. - PMC - PubMed
    1. McGovern BH. The epidemiology, natural history and prevention of hepatitis B: implications of HIV coinfection. Antivir Ther. 2007;12 Suppl 3:H3–13. - PubMed
    1. Yim HJ, Lok AS. Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology. 2006;43:S173–S181. - PubMed

LinkOut - more resources