Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jan;19(1):226-33.
doi: 10.1007/s10120-015-0464-5. Epub 2015 Jan 23.

Risk factors for selection of patients at high risk of recurrence or death after complete surgical resection in stage I gastric cancer

Ji Hyun Park  1 , Min-Hee Ryu  1 , Hwa Jung Kim  2 , Baek-Yeol Ryoo  1 , Changhoon Yoo  1 , Inkeun Park  1 , Young Soo Park  3 , Sung Tae Oh  4 , Jeong Hwan Yook  4 , Byung Sik Kim  4 , Yoon-Koo Kang  5
Affiliations

Risk factors for selection of patients at high risk of recurrence or death after complete surgical resection in stage I gastric cancer

Ji Hyun Park et al. Gastric Cancer. 2016 Jan.

Abstract

Background: The therapeutic benefit of adjuvant chemotherapy has not been proven in stage I gastric cancer (GC). The aim of this study was to identify stage I GC patients at high risk of recurrence or death.

Methods: We retrospectively reviewed the medical records of 2,783 patients with pathologically confirmed stage I GC who underwent curative surgical resection alone at Asan Medical Center between 2003 and 2007. The clinicopathologic parameters explored included age, sex, histologic differentiation, Lauren classification, size, location, multiplicity, stage, lymphovascular or perineural invasion, preoperative serum levels of tumor markers (carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4), and type of surgery.

Results: With a median follow-up of 54 months (range 0-60 months), 212 patients (7.6%) experienced recurrence or death, and the 5 -year recurrence-free survival (RFS) rate and overall survival rate were 89.9 and 93.4%, respectively. With a multivariate analysis, six factors (age over 65 years, male gender, stage IB GC, lymphovascular invasion, perineural invasion, and elevated level of carcinoembryonic antigen) were independent poor prognostic factors for RFS (p < 0.05). Patients with more than two of six poor risk factors had a 5-year RFS rate of 79%, whereas patients with fewer risk factors had a 5-year RFS rate of 97% (p <0.001).

Conclusions: In this study cohort, we identified six independent risk factors for RFS. The patients with more than two risk factors are expected to have significant risk of recurrence or death after curative resection and should be considered as candidates for adjuvant treatment.

Trial registration: ClinicalTrials.gov NCT01917552.

Keywords: Gastric cancer; Recurrence; Risk factor; Stage I.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Clin Oncol. 2004 Jul 15;22(14):2767-73 - PubMed
    1. J Gastric Cancer. 2011 Jun;11(2):69-77 - PubMed
    1. Hepatogastroenterology. 2002 Sep-Oct;49(47):1465-8 - PubMed
    1. Hepatogastroenterology. 2007 Mar;54(74):620-4 - PubMed
    1. Ann Surg Oncol. 2009 Jul;16(7):1896-902 - PubMed

Publication types

Associated data

LinkOut - more resources