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. 1989;37(4):341-3.
doi: 10.1007/BF00558497.

Plasma beta-endorphin, ACTH and cortisol secretion in man after nasal spray administration of calcitonin

R Franceschini  1 , A Cataldi, T Barreca, M Salvemini, E Rolandi
Affiliations

Plasma beta-endorphin, ACTH and cortisol secretion in man after nasal spray administration of calcitonin

R Franceschini et al. Eur J Clin Pharmacol. 1989.

Abstract

Beta-endorphin, ACTH and cortisol secretion were measured in twelve healthy adult males after nasal spray administration 200 IU salmon calcitonin. A significant increase in plasma beta-endorphin, from 19.2 ng/l under basal conditions to a peak of 27.1 ng/l at 30 min was recorded. Plasma ACTH and cortisol were not affected. In individual subjects the beta-endorphin level was increased in eight of the twelve, ACTH rose in three and cortisol did not change in any of them. The data indicate that calcitonin induced a beta-endorphin increase independent of enhanced corticotrophin-cortisol release.

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