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. 2016 Dec;49(6):934-940.
doi: 10.1016/j.jmii.2014.10.006. Epub 2014 Nov 11.

Risk factors of mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia

Chang-Pan Liu  1 , Shou-Chuan Shih  2 , Nai-Yu Wang  3 , Alice Y Wu  4 , Fang-Ju Sun  5 , Shan-Fan Chow  6 , Te-Li Chen  7 , Tsong-Rong Yan  8
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Free article

Risk factors of mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia

Chang-Pan Liu et al. J Microbiol Immunol Infect. 2016 Dec.
Free article

Abstract

Background/purpose: Identification of risks of mortality for carbapenem-resistant Acinetobacter baumannii (CRAB), with early implementation of an appropriate therapy, is crucial for the patients' outcome. The aim of this study was to survey mortality risk factors in 182 patients with CRAB bacteremia in a medical center in Taiwan.

Methods: A total of 182 isolates of CRAB bacteremia were collected from 2009 to 2012 in Mackay Memorial Hospital, Taipei, Taiwan These isolates were identified by using the genotypic method. Risk of attributable mortality analysis was carried out with a Cox proportional hazards model.

Results: The 182 CRAB isolates belonged to 38 different pulsotypes. The attributable mortality rate of the 182 patients was 58.24%. The risk factors for attributable mortality included intensive care unit stay [hazard ratio (HR): 2.27; p = 0.011], an Acute Physiology and Chronic Health Evaluation II score of >20 (HR: 2.19; p < 0.001), respiratory tract as the origin of bacteremia (HR: 3.40; p < 0.001), and previous use of ceftriaxone (HR: 2.51; p = 0.011). The appropriateness of antimicrobial therapy was 18.87% (20/106) in the mortality group versus 88.16% (67/76) in the survivor group (p < 0.001). The sensitivity of CRAB to colistin was 100% and to tigecycline was 40.11%.

Conclusion: The risk factors for mortality for CRAB included intensive care unit stay, a high Acute Physiology and Chronic Health Evaluation II score, respiratory tract as the origin of bacteremia, and previous use of ceftriaxone. Early implementation of an antimicrobial agent that had the highest in vitro activity against CRAB in patients at risk of CRAB bacteremia and high mortality may improve their outcome.

Keywords: Acinetobacter baumannii, bacteremia; mortality; risk factors.

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