P2X and P2Y receptors—role in the pathophysiology of the nervous system

doi:10.3390/ijms151223672

Review

. 2014 Dec 18;15(12):23672-704.

doi: 10.3390/ijms151223672.

P2X and P2Y receptors—role in the pathophysiology of the nervous system

Kamila Puchałowicz¹, Maciej Tarnowski², Irena Baranowska-Bosiacka³, Dariusz Chlubek⁴, Violetta Dziedziejko⁵

Affiliations

¹ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. kamila.puchalowicz@op.pl.
² Department of Physiology, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. maciejt@pum.edu.pl.
³ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. irena.bosiacka@pum.edu.pl.
⁴ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. dchlubek@pum.edu.pl.
⁵ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. viola@pum.edu.pl.

PMID: 25530618
PMCID: PMC4284787
DOI: 10.3390/ijms151223672

Review

P2X and P2Y receptors—role in the pathophysiology of the nervous system

Kamila Puchałowicz et al. Int J Mol Sci. 2014.

. 2014 Dec 18;15(12):23672-704.

doi: 10.3390/ijms151223672.

Authors

Kamila Puchałowicz¹, Maciej Tarnowski², Irena Baranowska-Bosiacka³, Dariusz Chlubek⁴, Violetta Dziedziejko⁵

Affiliations

¹ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. kamila.puchalowicz@op.pl.
² Department of Physiology, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. maciejt@pum.edu.pl.
³ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. irena.bosiacka@pum.edu.pl.
⁴ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. dchlubek@pum.edu.pl.
⁵ Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 72 Powstańców Wielkopolskich Street, Szczecin 70-111, Poland. viola@pum.edu.pl.

PMID: 25530618
PMCID: PMC4284787
DOI: 10.3390/ijms151223672

Abstract

Purinergic signalling plays a crucial role in proper functioning of the nervous system. Mechanisms depending on extracellular nucleotides and their P2 receptors also underlie a number of nervous system dysfunctions. This review aims to present the role of purinergic signalling, with particular focus devoted to role of P2 family receptors, in epilepsy, depression, neuropathic pain, nervous system neoplasms, such as glioma and neuroblastoma, neurodegenerative diseases like Parkinson's disease, Alzheimer's disease and multiple sclerosis. The above-mentioned conditions are associated with changes in expression of extracellular ectonucleotidases, P2X and P2Y receptors in neurons and glial cells, as well as releasing considerable amounts of nucleotides from activated or damaged nervous tissue cells into the extracellular space, which contributes to disturbance in purinergic signalling. The numerous studies indicate a potential possibility of using synthetic agonists/antagonists of P2 receptors in treatment of selected nervous system diseases. This is of particular significance, since numerous available agents reveal a low effectiveness and often produce side effects.

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[1] Fellin T., Pascual O., Haydon P.G. Astrocytes coordinate synaptic networks: Balanced excitation and inhibition. Physiology. 2006;21:208–215. doi: 10.1152/physiol.00161.2005. - DOI - PubMed

[2] Fellin T., Pascual O., Haydon P.G. Astrocytes coordinate synaptic networks: Balanced excitation and inhibition. Physiology. 2006;21:208–215. doi: 10.1152/physiol.00161.2005. - DOI - PubMed

[3] Falzoni S., Donvito G., di Virgilio F. Detecting adenosine triphosphate in the pericellular space. Interface Focus. 2013;3 doi: 10.1098/rsfs.2012.0101. - DOI - PMC - PubMed

[4] Falzoni S., Donvito G., di Virgilio F. Detecting adenosine triphosphate in the pericellular space. Interface Focus. 2013;3 doi: 10.1098/rsfs.2012.0101. - DOI - PMC - PubMed

[5] Helenius M., Jalkanen S., Yegutkin G. Enzyme-coupled assays for simultaneous detection of nanomolar ATP, ADP, AMP, adenosine, inosine and pyrophosphate concentrations in extracellular fluids. Biochim. Biophys. Acta. 2012;1823:1967–1975. doi: 10.1016/j.bbamcr.2012.08.001. - DOI - PubMed

[6] Helenius M., Jalkanen S., Yegutkin G. Enzyme-coupled assays for simultaneous detection of nanomolar ATP, ADP, AMP, adenosine, inosine and pyrophosphate concentrations in extracellular fluids. Biochim. Biophys. Acta. 2012;1823:1967–1975. doi: 10.1016/j.bbamcr.2012.08.001. - DOI - PubMed

[7] North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002;82:1013–1067. - PubMed

[8] North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002;82:1013–1067. - PubMed

[9] Abbracchio M.P., Burnstock G., Verkhratsky A., Zimmermann H. Purinergic signalling in the nervous system: An overview. Trends Neurosci. 2009;32:19–29. doi: 10.1016/j.tins.2008.10.001. - DOI - PubMed

[10] Abbracchio M.P., Burnstock G., Verkhratsky A., Zimmermann H. Purinergic signalling in the nervous system: An overview. Trends Neurosci. 2009;32:19–29. doi: 10.1016/j.tins.2008.10.001. - DOI - PubMed

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P2X and P2Y receptors—role in the pathophysiology of the nervous system

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P2X and P2Y receptors—role in the pathophysiology of the nervous system

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