Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease
- PMID: 2552313
- DOI: 10.1056/NEJM198910193211604
Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease
Abstract
Epstein-Barr virus (EBV) has been associated with serious or fatal lymphoproliferative disease in immunocompromised patients. EBV nuclear protein 2 and latent membrane protein are characteristically expressed in B lymphocytes proliferating in vitro in response to growth transformation by EBV. These two proteins are thought to be effectors of lymphocyte growth since they increase the expression of B-lymphocyte activation (CD23) and cell-adhesion (LFA 3 and ICAM 1) molecules in vitro. Using monoclonal antibody-immune microscopy, we have demonstrated that these two EBV proteins and their associated B-lymphocyte activation or adhesion molecules are expressed in the infiltrating B lymphocytes in immunocompromised patients with EBV lymphoproliferative disease. These monoclonal antibodies should be useful in the early diagnosis of EBV lymphoproliferative disease and in distinguishing it from other B-lymphocyte cancers associated with EBV, such as Burkitt's lymphoma. The finding of EBV nuclear protein 2 and latent membrane protein and their associated activation or adhesion molecules provides a further pathophysiologic link between EBV and the proliferation of B lymphocytes in immunocompromised patients.
Similar articles
-
Patterns of Epstein-Barr virus latent and replicative gene expression in Epstein-Barr virus B cell lymphoproliferative disorders after organ transplantation.Transplantation. 1994 Aug 15;58(3):317-24. Transplantation. 1994. PMID: 8053055
-
Epstein-Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA-2 and LMP1 cooperatively induce CD23.J Virol. 1990 May;64(5):2309-18. doi: 10.1128/JVI.64.5.2309-2318.1990. J Virol. 1990. PMID: 2157887 Free PMC article.
-
Transient expression of the Epstein-Barr virus LMP1 gene in human primary B cells induces cellular activation and DNA synthesis.Oncogene. 1992 Sep;7(9):1775-82. Oncogene. 1992. PMID: 1354347
-
T cell recognition of Epstein-Barr virus associated lymphomas.Cancer Surv. 1992;13:53-80. Cancer Surv. 1992. PMID: 1330300 Review.
-
[Biology of the Epstein-Barr virus].Ann Biol Clin (Paris). 1989;47(7):421-7. Ann Biol Clin (Paris). 1989. PMID: 2554764 Review. French.
Cited by
-
Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation.Proc Natl Acad Sci U S A. 1989 Dec;86(23):9558-62. doi: 10.1073/pnas.86.23.9558. Proc Natl Acad Sci U S A. 1989. PMID: 2556717 Free PMC article.
-
Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.J Virol. 1990 Jul;64(7):3407-16. doi: 10.1128/JVI.64.7.3407-3416.1990. J Virol. 1990. PMID: 2352328 Free PMC article.
-
PY motifs of Epstein-Barr virus LMP2A regulate protein stability and phosphorylation of LMP2A-associated proteins.J Virol. 2001 Jun;75(12):5711-8. doi: 10.1128/JVI.75.12.5711-5718.2001. J Virol. 2001. PMID: 11356981 Free PMC article.
-
TAF Family Proteins and MEF2C Are Essential for Epstein-Barr Virus Super-Enhancer Activity.J Virol. 2019 Jul 30;93(16):e00513-19. doi: 10.1128/JVI.00513-19. Print 2019 Aug 15. J Virol. 2019. PMID: 31167905 Free PMC article.
-
Frequency of multiple Epstein-Barr virus infections in T-cell-immunocompromised individuals.J Virol. 1996 Aug;70(8):4884-94. doi: 10.1128/JVI.70.8.4884-4894.1996. J Virol. 1996. PMID: 8763991 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
