Comment
doi: 10.4161/15384101.2014.980695.
DDX17: structured RNA recognition drives diverse outputs
Affiliations
- PMID: 25493410
- PMCID: PMC4615127
- DOI: 10.4161/15384101.2014.980695
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Comment
DDX17: structured RNA recognition drives diverse outputs
Cell Cycle.
2014.
No abstract available
Figures
DDX17 recognizes both primary sequence elements and secondary structures of RNAs. CLIP-seq analysis of DDX17-bound RNAs revealed that DDX17 recognizes mature cellular mRNAs enriched for CA- and CT-repeat elements. DDX17 is a member of the Microprocessor complex and facilitates pri-miRNA processing, but not through these repeat elements. Rather, DDX17 is localized to the stem region and cooperates with a previously described [GTA]CATC[CTA] element, and together may determine DDX17 binding to miRNAs. In the cytoplasm, DDX17 binds to viral RNAs by recognizing structured regions such as the intergenic stem loop on the RVFV S genomic RNA to inhibit viral RNA replication.
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Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.Cell. 2014 Aug 14;158(4):764-777. doi: 10.1016/j.cell.2014.06.023. Cell. 2014. PMID: 25126784 Free PMC article.
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