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Review
. 2014 Dec 4;5(12):e1552.
doi: 10.1038/cddis.2014.520.

Koschei the immortal and anti-aging drugs

M V Blagosklonny  1
Affiliations
Review

Koschei the immortal and anti-aging drugs

M V Blagosklonny. Cell Death Dis. .

Abstract

In Slavic folklore, Koschei the Immortal was bony, thin and lean. Was his condition caused by severe calorie restriction (CR)? CR deactivates the target of rapamycin pathway and slows down aging. But the life-extending effect of severe CR is limited by starvation. What if Koschei's anti-aging formula included rapamycin? And was rapamycin (or another rapalog) combined with commonly available drugs such as metformin, aspirin, propranolol, angiotensin II receptor blockers and angiotensin-converting enzyme inhibitors.

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Figures

Figure 1
Figure 1
Koshchey the Deathless by Ivan Bilibin, 1901
Figure 2
Figure 2
Insulin-resistance: two opposite conditions. Insulin resistance (IR) can be caused by the activation of mTOR and, paradoxically, by mTOR inhibition. In the first case, IR is detrimental for health, whereas in the second case it is benevolent, ,
See this image and copyright information in PMC

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