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Review
. 2016 Jan;22(1):42-51.
doi: 10.1177/1076029614561320. Epub 2014 Dec 3.

Flow Augmentation in Acute Ischemic Stroke

Golnaz Yadollahikhales  1 , Afshin Borhani-Haghighi  2 , Mohammad Torabi-Nami  3 , Randall Edgell  4 , Salvador Cruz-Flores  5
Affiliations
Free article
Review

Flow Augmentation in Acute Ischemic Stroke

Golnaz Yadollahikhales et al. Clin Appl Thromb Hemost. 2016 Jan.
Free article

Abstract

There is an urgent need for additional therapeutic options for acute ischemic stroke considering the major pitfalls of the options available. Herein, we briefly review the role of cerebral blood flow, collaterals, vasoreactivity, and reperfusion injury in acute ischemic stroke. Then, we reviewed pharmacological and interventional measures such as volume expansion and induced hypertension, intra-aortic balloon counterpulsation, partial aortic occlusion, extracranial-intracranial carotid bypass surgery, sphenopalatine ganglion stimulation, and transcranial laser therapy with regard to their effects on flow augmentation and neuroprotection.

Keywords: cerebral blood flow; cerebrovascular accident; extracranial–intracranial carotid bypass surgery; induced hypertension; intra-aortic balloon counterpulsation; ischemic stroke; neuroprotection; partial aortic occlusion; sphenopalatine ganglion stimulation; transcranial laser therapy.

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