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. 2015 Jan;3(1):78-82.
doi: 10.3892/br.2014.366. Epub 2014 Sep 26.

Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction

Weijie Wang  1 , Yujiao Zhang  2 , Mei Gao  3 , Jiangrong Wang  3 , Yinglong Hou  3
Affiliations

Effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction

Weijie Wang et al. Biomed Rep. 2015 Jan.

Abstract

The present study aimed to investigate the effect of rosuvastatin on atrial structural remodeling in rabbits with myocardial infarction (MI). The rabbits were randomly divided into 4 groups: The sham operation group (S; n=8), the MI group (MI; n=7), the group with low-dose rosuvastatin [Rs; 2.5 mg/(kg/d), n=7] and the group with high-dose rosuvastatin [Rl, 5 mg/(kg/d), n=8]. A rabbit MI model was established via ligation of the anterior descending coronary artery. After 8 weeks of intervention, the left atrial diameter (LAD), atrial collagen content, expression level of type I collagen and left ventricular ejection fraction (LVEF) were measured. LAD in the MI group was significantly larger than the S, Rs and Rl groups after 8 weeks. The left atrial collagen content of the MI group was also significantly greater than those observed in the other 3 groups. The expression of type I collagen in the MI group was significantly increased compared to the other 3 groups. However, LVEF of the MI group was lower compared to the other 3 groups. There were no significant differences between the Rs and Rl groups in the above indexes. In conclusion, rosuvastatin can improve post-MI atrial structural remodeling.

Keywords: atrial structural remodeling; myocardial infarction; rabbit; rosuvastatin.

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Figures

Figure 1
Figure 1
Hematoxylin and eosin staining of left atrial tissues in the sham operation (S), myocardial infarction (MI), low-dose rosuvastatin (Rs) and high-dose rosuvastatin (Rl) groups (magnification, x400).
Figure 2
Figure 2
Masson staining of left atrial tissues in the sham operation (S), myocardial infarction (MI), low-dose rosuvastatin (Rs) and high-dose rosuvastatin (Rl) groups (magnification, x400).
Figure 3
Figure 3
Expression of left atrial type I collagen in the myocardial infarction (MI), low-dose rosuvastatin (Rs), high-dose rosuvastatin (Rl) and sham operation (S) groups. Western blot analysis of left atrial type I collagen of the groups. GAPDH was used as a control. Collagen I, left atrial type I collagen.
See this image and copyright information in PMC

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References

    1. Abuissa H, O'Keefe JH, Bybee KA. Statins as anti-arrhythmics: a systematic review part II: effects on risk of ventricular arrhythmias. Clin Cardiol. 2009;32:549–552. - PMC - PubMed
    1. Ma YX, Li WH, Xie Q. Rosuvastatin inhibits TGF-beta1 expression and alleviates myocardial fibrosis in diabetic rats. Pharmazie. 2013;68:355–358. - PubMed
    1. Paraskevaidis IA, Iliodromitis EK, Ikonomidis I, et al. The effect of acute administration of statins on coronary microcirculation during the pre-revascularization period in patients with myocardial infraction. Atherosclerosis. 2012;223:184–189. - PubMed
    1. Hayashidani S, Tsutsui H, Shiomi T, et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation. 2002;105:868–873. - PubMed
    1. Jiang BH, Tardif JC, Sauvageau S, et al. Beneficial effects of atorvastatin on lung structural remodeling and function in ischemic heart failure. J Card Fail. 2010;16:679–688. - PubMed