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Review
. 2014 Dec;42(12):1261-5.
doi: 10.1016/j.ajic.2014.06.019. Epub 2014 Nov 25.

Middle East respiratory syndrome coronavirus: implications for health care facilities

Helena C Maltezou  1 , Sotirios Tsiodras  2
Affiliations
Review

Middle East respiratory syndrome coronavirus: implications for health care facilities

Helena C Maltezou et al. Am J Infect Control. 2014 Dec.

Abstract

Background: Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel coronavirus that causes a severe respiratory disease with high case fatality rate. Starting in March 2014, a dramatic increase of cases has occurred in the Arabian Peninsula, many of which were acquired in health care settings. As of May 9, 2014, 536 laboratory-confirmed cases and 145 deaths have been reported globally.

Methods: Review of publicly available data about MERS-CoV health care-associated transmission.

Results: We identified 11 events of possible or confirmed health care-associated transmission with high morbidity and mortality, mainly among patients with comorbidities. Health care workers are also frequently affected; however, they tend to have milder symptoms and better prognosis. Gaps in infection control were noted in all events. Currently, health care-associated outbreaks are playing a pivotal role in the evolution of the MERS-CoV epidemic in countries in the Arabian Peninsula.

Conclusion: There is a need to increase infection control capacity in affected areas and areas at increased risk of being affected to prevent transmission in health care settings. Vaccines and antiviral agents are urgently needed. Overall, our knowledge about the epidemiologic characteristics of MERS-CoV that impact health care transmission is very limited. As the MERS-CoV epidemic continues to evolve, issues concerning best infection control measures will arise, and studies to better define their effectiveness in real life are needed.

Keywords: Health care associated; Health care workers; Hospital; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; Outbreak.

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