Modulation of second messenger function in rat brain by in vivo alteration of receptor sensitivity: relevance to the mechanism of action of electroconvulsive therapy and antidepressants
- PMID: 2546177
- DOI: 10.1016/0278-5846(89)90002-x
Modulation of second messenger function in rat brain by in vivo alteration of receptor sensitivity: relevance to the mechanism of action of electroconvulsive therapy and antidepressants
Abstract
1. The second messengers cyclic AMP and inositol triphosphate are the intracellular mediators for a number of neurotransmitters for which receptors exist on brain neurons. 2. Up- or down-regulation of these receptors in general produce corresponding changes in the associated second messenger systems. 3. Chronic administration of antidepressants including electroconvulsive shock to rats produces a number of changes in cerebral receptors, notably down-regulation of beta-adrenergic and serotonin 5-HT2 receptors and up-regulation of alpha-1 adrenergic receptors. 4. The changes in receptor number induced by such antidepressant treatments are in general accompanied by corresponding changes in the associated second messenger reactions. 5. Antidepressant administration has also been shown to induce increased post-receptor mediated adenylate cyclase activity in cortical membranes, and similar effects have also been reported in striatum after chronic administration of neuroleptics. The relevance of these effects to the mechanism of action of the drugs is discussed.
Similar articles
-
Chronic antidepressant therapy and associated changes in central monoaminergic receptor functioning.Pharmacol Ther. 1983;21(1):1-33. doi: 10.1016/0163-7258(83)90065-7. Pharmacol Ther. 1983. PMID: 6312466 Review.
-
Agonist-stimulation of cerebral phosphoinositide turnover following long-term treatment with antidepressants.Adv Exp Med Biol. 1987;221:531-47. doi: 10.1007/978-1-4684-7618-7_38. Adv Exp Med Biol. 1987. PMID: 2829591
-
Differential effects of electroconvulsive shock and antidepressant drugs on serotonin-2 receptors in rat brain.Eur J Pharmacol. 1981 Feb 19;69(4):515-8. doi: 10.1016/0014-2999(81)90460-x. Eur J Pharmacol. 1981. PMID: 7250184
-
The effect of psychotropic drugs on the interaction of protein kinase C with second messenger systems in the rat cerebral cortex.Pol J Pharmacol. 1994 Jan-Apr;46(1-2):1-14. Pol J Pharmacol. 1994. PMID: 7981766 Review.
-
[Antidepressant drugs and central monoaminergic receptors].Yakubutsu Seishin Kodo. 1985 Dec;5(4):303-19. Yakubutsu Seishin Kodo. 1985. PMID: 2870595 Review. Japanese.
Cited by
-
Repetitive transcranial magnetic stimulation activates specific regions in rat brain.Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15635-40. doi: 10.1073/pnas.95.26.15635. Proc Natl Acad Sci U S A. 1998. PMID: 9861022 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical