The comparison of genotyping, antibiogram, and antimicrobial resistance genes between carbapenem-susceptible and -resistant Acinetobacter baumannii
- PMID: 25456639
- DOI: 10.1016/j.cimid.2014.10.002
The comparison of genotyping, antibiogram, and antimicrobial resistance genes between carbapenem-susceptible and -resistant Acinetobacter baumannii
Abstract
This study was conducted to explore the epidemiological and molecular differences between carbapenem-susceptible Acinetobacter baumannii (CSAB) and carbapenem-resistant A. baumannii (CRAB) isolates. Thirty-two CSAB and 55 CRAB isolates were collected in 2010. By multilocus sequence typing analysis, 31 (56%) CRAB isolates and 11 (34%) CSAB isolates belonged to ST2. Twenty-one (38%) CRAB isolates, and 4 (13%) CSAB isolates belonged to a new type, ST129. The blaIMP, blaVIM, and blaOXA-58-like were not detected in our study isolates. blaOXA-23 and blaOXA-24/40-like were not detected in all CSAB isolates. On the contrary, blaOXA-23 was detected in 51 (93%) CRAB isolates. Class 1 integron was detected in 19 (35%) CRAB isolates and 8 (25%) CSAB isolates (p>0.05). In conclusion, the ST2 and ST129 were the major sequence types in both CSAB and CRAB isolates. The blaOXA-23 is the primary carbapenem-resistance gene in CRAB isolates from hospitalized patients and the specimens collected from hospital environment.
Keywords: Acinetobacter baumannii; Carbapenem-resistant; Carbapenem-susceptible; MLST; PFGE.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Similar articles
-
OXA beta-lactamase-mediated carbapenem resistance in Acinetobacter baumannii.Indian J Med Microbiol. 2011 Jul-Sep;29(3):269-74. doi: 10.4103/0255-0857.83911. Indian J Med Microbiol. 2011. PMID: 21860108
-
Molecular Epidemiology of Carbapenem-Resistant Acinetobacter baumannii in a Tertiary Care Hospital in Egypt: Clonal Spread of blaOXA-23.Microb Drug Resist. 2018 Apr;24(3):269-277. doi: 10.1089/mdr.2017.0057. Epub 2017 Aug 7. Microb Drug Resist. 2018. PMID: 28783427
-
Molecular characterization of β-lactamase genes in clinical isolates of carbapenem-resistant Acinetobacter baumannii.Ann Clin Microbiol Antimicrob. 2017 Nov 16;16(1):75. doi: 10.1186/s12941-017-0248-3. Ann Clin Microbiol Antimicrob. 2017. PMID: 29145853 Free PMC article.
-
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology.Clin Microbiol Infect. 2006 Sep;12(9):826-36. doi: 10.1111/j.1469-0691.2006.01456.x. Clin Microbiol Infect. 2006. PMID: 16882287 Review.
-
Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in Greece: an extended review (2000-2015).Future Microbiol. 2017 Jul;12:801-815. doi: 10.2217/fmb-2016-0200. Epub 2017 Jun 12. Future Microbiol. 2017. PMID: 28604100 Review.
Cited by
-
Molecular epidemiology and characterization of multiple drug-resistant (MDR) clinical isolates of Acinetobacter baumannii.Int J Infect Dis. 2015 Dec;41:42-9. doi: 10.1016/j.ijid.2015.10.016. Epub 2015 Oct 27. Int J Infect Dis. 2015. PMID: 26518066 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
