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Review
. 2014 Nov-Dec;99(6):691-8.
doi: 10.9738/INTSURG-D-14-00067.1.

Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature

Sedat Belli  1 , Huseyin Ozgur Aytac, Erdal Karagulle, Hakan Yabanoglu, Fazilet Kayaselcuk, Sedat Yildirim
Affiliations
Review

Outcomes of surgical treatment of primary signet ring cell carcinoma of the colon and rectum: 22 cases reviewed with literature

Sedat Belli et al. Int Surg. 2014 Nov-Dec.

Abstract

Colorectal primary signet ring cell carcinoma (PSRCCR) is a rare entity with a dismal prognosis, mainly because of delayed diagnosis. The objective of this study was to investigate the clinicopathologic features and prognostic factors for PSRCCR. This is a retrospective study including the data of 22 patients with PSRCCR who underwent surgery. Patients were categorized by age, sex, tumor site, and stage. Fifteen patients were male. Median age was 40 years. Sites for metastases were lymph nodes (86.4%), peritoneum (40.9%), and liver (9.1%). Most of the patients (91%) had stage III or IV tumors. The rates of curative and palliative resections performed were equal. Mean overall survival and mean progression-free survival times were found to be 33.3 ± 7.1 months (95% confidence interval, 19.4-47.2 months) and 11.8 ± 3.5 months (95% confidence interval, 4.9-18.7 months), respectively. It was concluded that site of the tumor, presence of bowel obstruction, peritoneum and lung metastases, adjacent organ infiltration, TNM stage, and efficiency of surgery have significant effects on survival. All in all, these aggressive tumors are generally diagnosed at advanced stages. Depending on the situation, survival is shorter. A high degree of vigilance is required for these patients to avoid the negative impact of late diagnosis on survival.

Keywords: Colorectal cancer; Histopathology; Signet ring cell; Survival.

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Figures

Fig. 1
Fig. 1
Two cases in which the signet ring cells have invaded the mucosa of the (a) left colon and (b) rectum, as seen in these 2 different colon specimens (hematoxylin and eosin, ×100).
Fig. 2
Fig. 2
Using endoscopic biopsy prior to surgery, the signet ring cells can clearly be seen to have invaded the rectal mucosa (hematoxylin and eosin, ×100).
Fig. 3
Fig. 3
Kaplan-Meier overall survival curve (A); survival analysis according to the location of the tumor (B); and survival analysis of the patients who could or could not have R0 resection performed upon them (C).
See this image and copyright information in PMC

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References

    1. Almagro UA. Primary signet-ring carcinoma of the colon. Cancer. 1983;52(8):1453–1457. - PubMed
    1. Kang H, O'Connell JB, Maggard MA, Sack J, Ko CY. A. 10-year outcomes evaluation of mucinous and signet-ring cell carcinoma of the colon and rectum. Dis Colon Rectum. 2005;48(6):1161–1168. - PubMed
    1. Min BS, Kim NK, Ko YT, Baek SH, Lee KY, Sohn SK. Clinicopathological features of signet-ring cell carcinoma of the colon and rectum: a case-matched study. Hepatogastroenterology. 2009;56(93):984–988. - PubMed
    1. Casavilca Zambrano S, Sanchez Lihon J, Zavaleta A. Colon and rectum signet-ring cell carcinoma in the National Institute of Neoplastic Diseases. Rev Gastroenterol Peru. 2004;24(3):234–237. - PubMed
    1. Kaw LL, Jr, Punzalan CK, Crisostomo AC, Bowyer MW, Wherry DC. Surgical pathology of colorectal cancer in Filipinos: implications for clinical practice. J Am Coll Surg. 2002;195(2):188–195. - PubMed

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