Review
doi: 10.1007/978-3-662-45059-8_4.
Genomics, proteomics, and genetics of leptospira
Affiliations
- PMID: 25388132
- DOI: 10.1007/978-3-662-45059-8_4
Item in Clipboard
Review
Genomics, proteomics, and genetics of leptospira
Curr Top Microbiol Immunol.
2015.
Abstract
Recent advances in molecular genetics, such as the ability to construct defined mutants, have allowed the study of virulence factors and more generally the biology in Leptospira. However, pathogenic leptospires remain much less easily transformable than the saprophyte L. biflexa and further development and improvement of genetic tools are required. Here, we review tools that have been used to genetically manipulate Leptospira. We also describe the major advances achieved in both genomics and postgenomics technologies, including transcriptomics and proteomics.
Similar articles
-
Construction of a library of random mutants in the spirochete Leptospira biflexa using a mariner transposon.Methods Mol Biol. 2012;859:169-76. doi: 10.1007/978-1-61779-603-6_9. Methods Mol Biol. 2012. PMID: 22367871
-
Genetic manipulation of Leptospira biflexa.Curr Protoc Microbiol. 2007 Jun;Chapter 12:Unit 12E.4. doi: 10.1002/9780471729259.mc12e04s05. Curr Protoc Microbiol. 2007. PMID: 18770609
-
Leptospiral Genomics and Pathogenesis.Curr Top Microbiol Immunol. 2018;415:189-214. doi: 10.1007/82_2018_87. Curr Top Microbiol Immunol. 2018. PMID: 29696440 Review.
-
Comparative and functional genomic analyses of iron transport and regulation in Leptospira spp.J Bacteriol. 2006 Nov;188(22):7893-904. doi: 10.1128/JB.00711-06. Epub 2006 Sep 15. J Bacteriol. 2006. PMID: 16980464 Free PMC article.
-
Toolbox of Molecular Techniques for Studying Leptospira Spp.Curr Top Microbiol Immunol. 2018;415:141-162. doi: 10.1007/82_2017_45. Curr Top Microbiol Immunol. 2018. PMID: 28849314 Review.
Cited by
-
Advances and challenges in barcoding pathogenic and environmental Leptospira.Parasitology. 2018 Apr;145(5):595-607. doi: 10.1017/S0031182017001147. Epub 2017 Jul 18. Parasitology. 2018. PMID: 28716157 Free PMC article. Review.
-
Pathogenic Leptospires Modulate Protein Expression and Post-translational Modifications in Response to Mammalian Host Signals.Front Cell Infect Microbiol. 2017 Aug 9;7:362. doi: 10.3389/fcimb.2017.00362. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28848720 Free PMC article.
-
Temperature and Oxidative Stress as Triggers for Virulence Gene Expression in Pathogenic Leptospira spp.Front Microbiol. 2017 May 9;8:783. doi: 10.3389/fmicb.2017.00783. eCollection 2017. Front Microbiol. 2017. PMID: 28536558 Free PMC article.
-
Role of Supramolecule ErpY-Like Lipoprotein of Leptospira in Thrombin-Catalyzed Fibrin Clot Inhibition and Binding to Complement Factors H and I, and Its Diagnostic Potential.Infect Immun. 2019 Nov 18;87(12):e00536-19. doi: 10.1128/IAI.00536-19. Print 2019 Dec. Infect Immun. 2019. PMID: 31548314 Free PMC article.
-
Pathogenic Leptospira: Advances in understanding the molecular pathogenesis and virulence.Open Vet J. 2018;8(1):13-24. doi: 10.4314/ovj.v8i1.4. Epub 2018 Jan 20. Open Vet J. 2018. PMID: 29445617 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
