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. 1989 Apr;22(2):107-11.
doi: 10.1016/0165-5728(89)90040-4.

Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection

E Lavi  1 , A Suzumura, E M Murray, D H Silberberg, S R Weiss
Affiliations

Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection

E Lavi et al. J Neuroimmunol. 1989 Apr.

Abstract

H-2 class I antigens, but not class II antigens, were detected on the surface of glial cells persistently infected with mouse hepatitis virus strain A59 (MHV-A59) as late as 90 days post-infection. Uninfected glial cells remained negative for H-2 class I and class II surface antigens. We have previously shown that conditioned media from infected glial cell cultures (supernatants) contain a factor unrelated to infectious virus and capable of inducing H-2 class I antigens on uninfected glial cells. The synthesis of this factor appears to be dependent on production of infectious virus since the H-2 inducing activity could not be detected 3 days following the addition of neutralizing antibodies to the cultures. This suggests that H-2 inducing activity contains an unstable component, the synthesis of which is dependent on continual virus production. Persistent MHV infection and H-2 class I antigen expression may play a role in MHV-induced demyelination.

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