DNA methylation: old dog, new tricks?

doi:10.1038/nsmb.2910

. 2014 Nov;21(11):949-54.

doi: 10.1038/nsmb.2910.

DNA methylation: old dog, new tricks?

Cornelia G Spruijt¹, Michiel Vermeulen²

Affiliations

¹ Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands.
² 1] Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands. [3] Cancer Genomics Netherlands, the Netherlands.

PMID: 25372310
DOI: 10.1038/nsmb.2910

DNA methylation: old dog, new tricks?

Cornelia G Spruijt et al. Nat Struct Mol Biol. 2014 Nov.

. 2014 Nov;21(11):949-54.

doi: 10.1038/nsmb.2910.

Authors

Cornelia G Spruijt¹, Michiel Vermeulen²

Affiliations

¹ Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands.
² 1] Department of Molecular Cancer Research, University Medical Center Utrecht, Utrecht, the Netherlands. [2] Department of Molecular Biology, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, the Netherlands. [3] Cancer Genomics Netherlands, the Netherlands.

PMID: 25372310
DOI: 10.1038/nsmb.2910

Abstract

DNA methylation is an epigenetic modification that is generally associated with repression of transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent high-throughput genomic and proteomic screenings, DNA methylation can also have different outcomes, including activation of transcription. This is evidenced by the fact that transcription factors can interact with methylated DNA sequences. Furthermore, in certain cellular contexts, genes containing methylated promoters are highly transcribed. Interestingly, this uncoupling between methylated DNA and repression of transcription seems to be particularly evident in germ cells and pluripotent cells. Thus, contrary to previous assumptions, DNA methylation is not exclusively associated with repression of transcription initiation.

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[1] EMBO J. 1992 Jan;11(1):327-33 - PubMed

[2] EMBO J. 1992 Jan;11(1):327-33 - PubMed

[3] Cell. 2013 Apr 11;153(2):480-92 - PubMed

[4] Cell. 2013 Apr 11;153(2):480-92 - PubMed

[5] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6481-6 - PubMed

[6] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6481-6 - PubMed

[7] J Biol Chem. 2013 Nov 29;288(48):34287-94 - PubMed

[8] J Biol Chem. 2013 Nov 29;288(48):34287-94 - PubMed

[9] Cell Stem Cell. 2008 Feb 7;2(2):160-9 - PubMed

[10] Cell Stem Cell. 2008 Feb 7;2(2):160-9 - PubMed

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DNA methylation: old dog, new tricks?

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DNA methylation: old dog, new tricks?

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