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Review
. 2014 Sep;11(3):182-90.
doi: 10.7497/j.issn.2095-3941.2014.03.004.

Hepatitis B virus X protein accelerates the development of hepatoma

Xiao-Dong Zhang  1 , Yuan Wang  1 , Li-Hong Ye  1
Affiliations
Review

Hepatitis B virus X protein accelerates the development of hepatoma

Xiao-Dong Zhang et al. Cancer Biol Med. 2014 Sep.

Abstract

The chronic infection of hepatitis B virus (HBV) is closely related to the occurrence and development of hepatocellular carcinoma (HCC). Accumulated evidence has shown that HBV X protein (HBx protein) is a multifunctional regulator with a crucial role in hepatocarcinogenesis. However, information on the mechanism by which HBV induces HCC is lacking. This review focuses on the pathological functions of HBx in HBV-induced hepatocarcinogenesis. As a transactivator, HBx can modulate nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and transcription factor AP-2. Moreover, HBx can affect regulatory non-coding RNAs (ncRNAs) including microRNAs and long ncRNAs (lncRNAs), such as miRNA-205 and highly upregulated in liver cancer (HULC), respectively. HBx is also involved in epigenetic modification, including methylation and acetylation. HBx interacts with various signal-transduction pathways, such as protein kinase B/Akt, Wnt/β-catenin, signal transducer and activator of transcription, and NF-κB pathways. Moreover, HBx affects cellular fate by shifting the balance toward cell survival. HBx may lead to the loss of apoptotic functions or directly contributes to oncogenesis by achieving transforming functions, which induce hepatocarcinogenesis. Additionally, HBx can modulate apoptosis and immune response by direct or indirect interaction with host factors. We conclude that HBx hastens the development of hepatoma.

Keywords: HBV X protein (HBx protein); Hepatocellular carcinoma (HCC); hepatitis B virus (HBV); hepatocarcinogenesis.

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Conflict of interest statement

No potential conflicts of interest are disclosed.

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References

    1. Kew MC. Epidemiology of chronic hepatitis B virus infection, hepatocellular carcinoma, and hepatitis B virus-induced hepatocellular carcinoma. Pathol Biol (Paris) 2010;58:273-277 - PubMed
    1. Zhang X, Zhang H, Ye L.Effects of hepatitis B virus X protein on the development of liver cancer. J Lab Clin Med 2006;147:58-66 - PubMed
    1. Seeger C, Mason WS. Hepatitis B virus biology. Microbiol Mol Biol Rev 2000;64:51-68 - PMC - PubMed
    1. Kodama K, Ogasawara N, Yoshikawa H, Murakami S.Nucleotide sequence of a cloned woodchuck hepatitis virus genome: evolutional relationship between hepadnaviruses. J Virol 1985;56:978-986 - PMC - PubMed
    1. Nakatake H, Chisaka O, Yamamoto S, Matsubara K, Koshy R.Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication. Virology 1993;195:305-314 - PubMed

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