The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26
- PMID: 2535740
- PMCID: PMC247696
- DOI: 10.1128/JVI.63.1.398-402.1989
The ets sequence is required for induction of erythroblastosis in chickens by avian retrovirus E26
Abstract
E26 is a replication-defective avian retrovirus that causes an erythroblastic leukemia in vivo and transforms hematopoietic precursor cells of both the erythroid and the myeloid lineages in vitro. The E26 genome contains two sets of cell-derived sequences, ets and myb. myb sequences are also present in avian myeloblastosis virus, which transforms myeloblasts exclusively. To determine whether the ets sequence is responsible for the erythroid specificity of E26, we analyzed the transforming activities of several viruses carrying mutations in the ets sequence constructed in vitro. The mutant viruses retained the ability to transform myeloid cells in vitro, indicating that the myb oncogene is sufficient for this viral function. However, the ets-deficient viruses did not cause an overt leukemia in chickens. The results indicate that the ets sequence is required for the induction of erythroblastosis by E26.
Similar articles
-
Avian erythroblastosis virus E26: nucleotide sequence of the tripartite onc gene and of the LTR, and analysis of the cellular prototype of the viral ets sequence.Virology. 1984 Dec;139(2):330-9. doi: 10.1016/0042-6822(84)90378-7. Virology. 1984. PMID: 6097027
-
Tripartite structure of the avian erythroblastosis virus E26 transforming gene.Nature. 1983 Nov 24-30;306(5941):391-5. doi: 10.1038/306391a0. Nature. 1983. PMID: 6316155
-
The various domains of v-myb and v-ets oncogenes of E26 retrovirus contribute differently, but cooperatively, in transformation of hematopoietic lineages.Oncogene. 1992 Nov;7(11):2231-41. Oncogene. 1992. PMID: 1331935
-
The ets genes in cells and viruses: implications for leukemias and other human diseases.Ann N Y Acad Sci. 1987;511:171-91. doi: 10.1111/j.1749-6632.1987.tb36246.x. Ann N Y Acad Sci. 1987. PMID: 2830823 Review. No abstract available.
-
Molecular analysis of the ets genes and their products.Crit Rev Oncog. 1990;1(4):409-36. Crit Rev Oncog. 1990. PMID: 1964597 Review.
Cited by
-
The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins.EMBO J. 1991 May;10(5):1127-34. doi: 10.1002/j.1460-2075.1991.tb08053.x. EMBO J. 1991. PMID: 1850695 Free PMC article.
-
The PU.1/Spi-1 proto-oncogene is a transcriptional regulator of a lentivirus promoter.J Virol. 1993 Jul;67(7):3885-90. doi: 10.1128/JVI.67.7.3885-3890.1993. J Virol. 1993. PMID: 8389910 Free PMC article.
-
Functional interference between the Spi-1/PU.1 oncoprotein and steroid hormone or vitamin receptors.EMBO J. 1993 Dec 15;12(13):5089-96. doi: 10.1002/j.1460-2075.1993.tb06203.x. EMBO J. 1993. PMID: 8262052 Free PMC article.
-
Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor.J Virol. 1992 Jan;66(1):160-6. doi: 10.1128/JVI.66.1.160-166.1992. J Virol. 1992. PMID: 1727478 Free PMC article.
-
Transcription and cancer.Br J Cancer. 1991 May;63(5):651-62. doi: 10.1038/bjc.1991.151. Br J Cancer. 1991. PMID: 1645561 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
