Intrinsically disordered proteins and multicellular organisms

doi:10.1016/j.semcdb.2014.09.025

Review

. 2015 Jan:37:44-55.

doi: 10.1016/j.semcdb.2014.09.025. Epub 2014 Oct 13.

Intrinsically disordered proteins and multicellular organisms

A Keith Dunker¹, Sarah E Bondos², Fei Huang³, Christopher J Oldfield⁴

Affiliations

¹ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: kedunker@iu.edu.
² Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843, United States. Electronic address: SEBondos@medicine.tamhsc.edu.
³ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: huangfei@umail.iu.edu.
⁴ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: cjoldfie@iu.edu.

PMID: 25307499
DOI: 10.1016/j.semcdb.2014.09.025

Review

Intrinsically disordered proteins and multicellular organisms

A Keith Dunker et al. Semin Cell Dev Biol. 2015 Jan.

. 2015 Jan:37:44-55.

doi: 10.1016/j.semcdb.2014.09.025. Epub 2014 Oct 13.

Authors

A Keith Dunker¹, Sarah E Bondos², Fei Huang³, Christopher J Oldfield⁴

Affiliations

¹ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: kedunker@iu.edu.
² Department of Molecular and Cellular Medicine, Texas A&M Health Science Center, College Station, TX 77843, United States. Electronic address: SEBondos@medicine.tamhsc.edu.
³ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: huangfei@umail.iu.edu.
⁴ Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University Schools of Medicine and Informatics, Indianapolis, IN 46202, United States. Electronic address: cjoldfie@iu.edu.

PMID: 25307499
DOI: 10.1016/j.semcdb.2014.09.025

Abstract

Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.

Keywords: Alternative splicing; Cell cycle; Differentiation; Intrinsic disorder; Post-translational modification; Signaling.

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Intrinsically disordered proteins and multicellular organisms

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Intrinsically disordered proteins and multicellular organisms

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