Chaperone-mediated autophagy: roles in neurodegeneration

doi:10.1186/2047-9158-3-20

Review

. 2014 Sep 21:3:20.

doi: 10.1186/2047-9158-3-20. eCollection 2014.

Chaperone-mediated autophagy: roles in neurodegeneration

Gang Wang¹, Zixu Mao¹

Affiliations

Affiliation

¹ Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA ; Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.

PMID: 25276349
PMCID: PMC4177711
DOI: 10.1186/2047-9158-3-20

Review

Chaperone-mediated autophagy: roles in neurodegeneration

Gang Wang et al. Transl Neurodegener. 2014.

. 2014 Sep 21:3:20.

doi: 10.1186/2047-9158-3-20. eCollection 2014.

Authors

Gang Wang¹, Zixu Mao¹

Affiliation

¹ Departments of Pharmacology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA ; Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.

PMID: 25276349
PMCID: PMC4177711
DOI: 10.1186/2047-9158-3-20

Abstract

Chaperone-mediated autophagy (CMA) selectively delivers cytosolic proteins with an exposed CMA-targeting motif to lysosomes for degradation and plays an important role in protein quality control and cellular homeostasis. A growing body of evidence supports the hypothesis that CMA dysfunction may be involved in the pathogenic process of neurodegenerative diseases. Both down-regulation and compensatory up-regulation in CMA activities have been observed in association with neurodegenerative conditions. Recent studies have revealed several new mechanisms by which CMA function may be involved in the regulation of factors critical for neuronal viability and homeostasis. Here, we summarize these recent advances in the understanding of the relationship between CMA dysfunction and neurodegeneration and discuss the therapeutic potential of targeting CMA in the treatment of neurodegenerative diseases.

Keywords: Alzheimer’s disease; Chaperone-mediated autophagy; Neurodegeneration; Parkinson’s disease; Protein posttranslational modifications.

PubMed Disclaimer

Figures

**Figure 1**
**Steps and regulation of CMA.** “X” represents local region or site of regulation.

See this image and copyright information in PMC

Cited by

Association of GALC, ZNF184, IL1R2 and ELOVL7 With Parkinson's Disease in Southern Chinese.
Li G, Cui S, Du J, Liu J, Zhang P, Fu Y, He Y, Zhou H, Ma J, Chen S. Li G, et al. Front Aging Neurosci. 2018 Dec 13;10:402. doi: 10.3389/fnagi.2018.00402. eCollection 2018. Front Aging Neurosci. 2018. PMID: 30618709 Free PMC article.
Neurodegeneration and Astrogliosis in the Human CA1 Hippocampal Subfield Are Related to hsp90ab1 and bag3 in Alzheimer's Disease.
Gonzalez-Rodriguez M, Villar-Conde S, Astillero-Lopez V, Villanueva-Anguita P, Ubeda-Banon I, Flores-Cuadrado A, Martinez-Marcos A, Saiz-Sanchez D. Gonzalez-Rodriguez M, et al. Int J Mol Sci. 2021 Dec 23;23(1):165. doi: 10.3390/ijms23010165. Int J Mol Sci. 2021. PMID: 35008592 Free PMC article.
Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina.
Notomi S, Ishihara K, Efstathiou NE, Lee JJ, Hisatomi T, Tachibana T, Konstantinou EK, Ueta T, Murakami Y, Maidana DE, Ikeda Y, Kume S, Terasaki H, Sonoda S, Blanz J, Young L, Sakamoto T, Sonoda KH, Saftig P, Ishibashi T, Miller JW, Kroemer G, Vavvas DG. Notomi S, et al. Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23724-23734. doi: 10.1073/pnas.1906643116. Epub 2019 Nov 7. Proc Natl Acad Sci U S A. 2019. PMID: 31699817 Free PMC article.
The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration.
Hu YB, Dammer EB, Ren RJ, Wang G. Hu YB, et al. Transl Neurodegener. 2015 Sep 30;4:18. doi: 10.1186/s40035-015-0041-1. eCollection 2015. Transl Neurodegener. 2015. PMID: 26448863 Free PMC article. Review.
Chaperone-Mediated Autophagy and Its Implications for Neurodegeneration and Cancer.
Assaye MA, Gizaw ST. Assaye MA, et al. Int J Gen Med. 2022 Jun 15;15:5635-5649. doi: 10.2147/IJGM.S368364. eCollection 2022. Int J Gen Med. 2022. PMID: 35734200 Free PMC article. Review.

See all "Cited by" articles

References

1. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8(11):931–937. doi: 10.1038/nrm2245. - DOI - PubMed
1. Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012;22(8):407–417. doi: 10.1016/j.tcb.2012.05.006. - DOI - PMC - PubMed
1. Wang X, Pattison JS, Su H. Posttranslational modification and quality control. Circ Res. 2013;112(2):367–381. doi: 10.1161/CIRCRESAHA.112.268706. - DOI - PMC - PubMed
1. Orenstein SJ, Cuervo AM. Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol. 2010;21(7):719–726. doi: 10.1016/j.semcdb.2010.02.005. - DOI - PMC - PubMed
1. Chiang HL, Dice JF. Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem. 1988;263(14):6797–6805. - PubMed

Publication types

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations

[1] Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8(11):931–937. doi: 10.1038/nrm2245. - DOI - PubMed

[2] Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol. 2007;8(11):931–937. doi: 10.1038/nrm2245. - DOI - PubMed

[3] Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012;22(8):407–417. doi: 10.1016/j.tcb.2012.05.006. - DOI - PMC - PubMed

[4] Kaushik S, Cuervo AM. Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol. 2012;22(8):407–417. doi: 10.1016/j.tcb.2012.05.006. - DOI - PMC - PubMed

[5] Wang X, Pattison JS, Su H. Posttranslational modification and quality control. Circ Res. 2013;112(2):367–381. doi: 10.1161/CIRCRESAHA.112.268706. - DOI - PMC - PubMed

[6] Wang X, Pattison JS, Su H. Posttranslational modification and quality control. Circ Res. 2013;112(2):367–381. doi: 10.1161/CIRCRESAHA.112.268706. - DOI - PMC - PubMed

[7] Orenstein SJ, Cuervo AM. Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol. 2010;21(7):719–726. doi: 10.1016/j.semcdb.2010.02.005. - DOI - PMC - PubMed

[8] Orenstein SJ, Cuervo AM. Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol. 2010;21(7):719–726. doi: 10.1016/j.semcdb.2010.02.005. - DOI - PMC - PubMed

[9] Chiang HL, Dice JF. Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem. 1988;263(14):6797–6805. - PubMed

[10] Chiang HL, Dice JF. Peptide sequences that target proteins for enhanced degradation during serum withdrawal. J Biol Chem. 1988;263(14):6797–6805. - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Chaperone-mediated autophagy: roles in neurodegeneration

Affiliation

Chaperone-mediated autophagy: roles in neurodegeneration

Authors

Affiliation

Abstract

Figures

Similar articles

Cited by

References

Publication types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Figures

Similar articles

Cited by

References

Publication types

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources