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. 1989 May;63(5):2348-51.
doi: 10.1128/JVI.63.5.2348-2351.1989.

Limited temperature-sensitive transactivation by mutant adenovirus type 2 E1a proteins

M L Fahnestock  1 , J B Lewis
Affiliations

Limited temperature-sensitive transactivation by mutant adenovirus type 2 E1a proteins

M L Fahnestock et al. J Virol. 1989 May.

Abstract

A series of linker-scanning and deletion mutations was generated in the transactivating domain of the larger, 289-amino-acid-residue E1a protein of adenovirus type 2. Mutant genes were recombined into virus to assay the ability of the variant E1a proteins to activate expression of an E1a-dependent viral gene during infection. Results of assays performed at 32, 37, and 40 degrees C indicated that at least 2 of the 10 mutants tested showed limited temperature sensitivity for transactivation.

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References

    1. Cell. 1979 Jul;17(3):683-9 - PubMed
    1. J Virol. 1989 Apr;63(4):1495-504 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Aug;76(8):3665-9 - PubMed
    1. Proc Natl Acad Sci U S A. 1981 Oct;78(10):6121-5 - PubMed
    1. Nature. 1982 Feb 4;295(5848):380-4 - PubMed

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