Comparative Study
doi: 10.1093/nar/17.4.1733.
A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'
Affiliations
- PMID: 2522186
- PMCID: PMC331831
- DOI: 10.1093/nar/17.4.1733
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Comparative Study
A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'
Nucleic Acids Res.
.
Free PMC article
Erratum in
- Nucleic Acids Res 1989 Aug 25;17(16):6777
Abstract
N is a tissue-specific, Sm-epitope bearing, snRNP-associated protein found predominantly in brain. The cDNA sequence encoding human N is compared to those for rat N and human B/B'. The amino acid sequences of human and rat N are 100% conserved. Although the amino acid sequences of N and B/B' are very similar to each other, B/B' contains 50 amino acids which are not present in N. On Northern blots the cDNAs encoding N and B/B' recognize two different RNA species. A comparison of the codon usage, as specified by the open reading frames of N and B/B' as well as results from Southern blots, show that N and B/B' are derived from different genes.
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