Resveratrol and stroke: from chemistry to medicine
- PMID: 25219659
- DOI: 10.2174/1567202611666140912114833
Resveratrol and stroke: from chemistry to medicine
Abstract
Stroke is one of the most common cardiovascular diseases and is known as a leading cause of death in the world. Despite to its high prevalence, there are limited effective therapeutic strategies for stroke till now. However, oxidative stress plays an important role in the pathogenesis of stroke and therefore, antioxidant therapy could be used as a new therapeutic strategy. Among the antioxidants, some natural compounds are very interesting due to their low adverse effects. Resveratrol (3, 5, 4'-trihydroxystilbene) is a natural polyphenolic antioxidant found in grape skin, grape products, and peanuts as well as in red wine. In recent years, much attention has been paid to resveratrol due to its wide range of antioxidant actions. Resveratrol possesses cardioprotective actions through stimulation of nitric oxide production as well as antioxidative and anti-inflammatory effects. Here we review the available literatures on beneficial role of resveratrol on ischemic stroke. We also provide information about chemistry, sources, bioavailability, as well as clinical impacts of resveratrol.
Similar articles
-
From resveratrol to its derivatives: new sources of natural antioxidant.Curr Med Chem. 2013;20(8):1005-17. Curr Med Chem. 2013. PMID: 23210785 Review.
-
Resveratrol as a therapeutic agent for neurodegenerative diseases.Mol Neurobiol. 2010 Jun;41(2-3):375-83. doi: 10.1007/s12035-010-8111-y. Epub 2010 Mar 21. Mol Neurobiol. 2010. PMID: 20306310 Free PMC article. Review.
-
Recent advances of resveratrol in nanostructured based delivery systems and in the management of HIV/AIDS.J Control Release. 2014 Nov 28;194:178-88. doi: 10.1016/j.jconrel.2014.09.002. Epub 2014 Sep 11. J Control Release. 2014. PMID: 25217813 Review.
-
Chemistry, stability and bioavailability of resveratrol.Med Chem. 2014 May;10(3):237-45. doi: 10.2174/15734064113096660053. Med Chem. 2014. PMID: 24329932 Review.
-
Biological effects of resveratrol.Life Sci. 2000 Jan 14;66(8):663-73. doi: 10.1016/s0024-3205(99)00410-5. Life Sci. 2000. PMID: 10680575 Review.
Cited by
-
Maternal resveratrol consumption and its programming effects on metabolic health in offspring mechanisms and potential implications.Biosci Rep. 2018 Mar 9;38(2):BSR20171741. doi: 10.1042/BSR20171741. Print 2018 Apr 27. Biosci Rep. 2018. PMID: 29437902 Free PMC article. Review.
-
A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke.Heliyon. 2024 Jul 5;10(14):e34121. doi: 10.1016/j.heliyon.2024.e34121. eCollection 2024 Jul 30. Heliyon. 2024. PMID: 39082038 Free PMC article. Review.
-
Fluoride Intensifies Hypercaloric Diet-Induced ER Oxidative Stress and Alters Lipid Metabolism.PLoS One. 2016 Jun 23;11(6):e0158121. doi: 10.1371/journal.pone.0158121. eCollection 2016. PLoS One. 2016. PMID: 27336443 Free PMC article.
-
MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice.J Am Heart Assoc. 2016 Sep 15;5(9):e003615. doi: 10.1161/JAHA.116.003615. J Am Heart Assoc. 2016. PMID: 27633389 Free PMC article.
-
Resveratrol Regulates BDNF, trkB, PSA-NCAM, and Arc Expression in the Rat Cerebral Cortex after Bilateral Common Carotid Artery Occlusion and Reperfusion.Nutrients. 2019 May 1;11(5):1000. doi: 10.3390/nu11051000. Nutrients. 2019. PMID: 31052460 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical