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Review
. 2014 Oct;24(7):267-72.
doi: 10.1016/j.tcm.2014.07.005. Epub 2014 Aug 2.

miR-22 in cardiac remodeling and disease

Zhan-Peng Huang  1 , Da-Zhi Wang  2
Affiliations
Review

miR-22 in cardiac remodeling and disease

Zhan-Peng Huang et al. Trends Cardiovasc Med. 2014 Oct.

Abstract

Regulation of gene expression during cardiac development and remodeling is very complicated, involving epigenetic, transcriptional, post-transcriptional, and translational regulation. Our understanding of the molecular mechanisms underlying cardiac remodeling is still far from complete. MicroRNAs are a class of small non-coding RNAs that have been shown to play critical roles in gene regulation in cardiovascular biology and disease. microRNA-22 (miR-22) is an evolutionally conserved miRNA that is highly expressed in the heart. Recent studies uncovered miR-22 as an important regulator for cardiac remodeling. miR-22 modulates the expression and function of genes involved in hypertrophic response, sarcomere reorganization, and metabolic program shift during cardiac remodeling. In this review, we will focus on the recent findings of miR-22 in cardiac remodeling and the therapeutic potential of this miRNA in the treatment of related defects resulting from adverse cardiac remodeling.

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Figures

Figure 1
Figure 1
Schematic depiction of miR-22 function in the regulation of cardiac remodeling. A transverse view of heart, indicated by the green dashed line in the heart model, is used to show the functional role of miR-22 in cardiac remodeling, including cardiac hypertrophy, dilated cardiomyopathy and fibrosis. The red areas in the ventricle wall of the dilated heart designate fibrosis lesions.
Figure 2
Figure 2
Schematic depiction of miR-22 function in cardiomyocytes. Several miR-22 targets (PurB, Sirt1, etc) and regulatory biological processes (Contraction and metabolism) are highlighted. Ac: acetyl groups; H: histone; HDAC4: histone deacetylase 4; MyoCD: myocardin; PGC-1〈: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; PPAR〈: peroxisome proliferator activated receptor alpha; PurB: purine rich element binding protein B; Sirt1: sirtuin 1; SRF: serum response factor.
See this image and copyright information in PMC

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References

    1. Hill JA, Olson EN. Cardiac plasticity. N Engl J Med. 2008;358:1370–1380. - PubMed
    1. Reinhart BJ, et al. MicroRNAs in plants. Genes Dev. 2002;16:1616–1626. - PMC - PubMed
    1. Lagos-Quintana M, et al. Identification of novel genes coding for small expressed RNAs. Science. 2001;294:853–858. - PubMed
    1. Lau NC, et al. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science. 2001;294:858–862. - PubMed
    1. Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans. Science. 2001;294:862–864. - PubMed

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