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doi: 10.1016/j.ccr.2014.08.009.
FAL1ing inside an amplicon
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- PMID: 25203317
- DOI: 10.1016/j.ccr.2014.08.009
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FAL1ing inside an amplicon
Cancer Cell.
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Free article
Abstract
Frequently amplified regions of the cancer genome contain well-known oncogenes. In this issue of Cancer Cell, Hu and colleagues discover that FAL1, a long noncoding RNA is encoded in one of these regions. FAL1 acts as an oncogene by stabilizing BMI1, which results in the repression of CDKN1A expression.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.Cancer Cell. 2014 Sep 8;26(3):344-357. doi: 10.1016/j.ccr.2014.07.009. Cancer Cell. 2014. PMID: 25203321 Free PMC article.
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