Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Oct;25(9-10):384-400.
doi: 10.1007/s00335-014-9543-x. Epub 2014 Aug 29.

Genetics of diabetes complications

Sami Alkayyali  1 , Valeriya Lyssenko
Affiliations
Review

Genetics of diabetes complications

Sami Alkayyali et al. Mamm Genome. 2014 Oct.

Abstract

Chronic hyperglycemia and duration of diabetes are the major risk factors associated with development of micro- and macrovascular complications of diabetes. Although it is believed that hyperglycemia induces damage to the particular cell subtypes, e.g., mesangial cells in the renal glomerulus, capillary endothelial cells in the retina, and neurons and Schwann cells in peripheral nerves, the exact mechanisms underlying these damaging defects are not yet well understood. Clustering of micro- and macrovascular complications in families of patients with diabetes suggests a strong genetic susceptibility. However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes. It is, therefore, obvious that the accumulation of more data from larger studies and better phenotypically characterized cohorts is needed to facilitate genetic discoveries and unravel novel insights into the pathogenesis of diabetic complications.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Diabetes. 2012 Aug;61(8):2187-94 - PubMed
    1. Diabetes. 2005 Aug;54(8):2320-7 - PubMed
    1. Nat Genet. 2009 Mar;41(3):334-41 - PubMed
    1. Diabetes Care. 2008 Nov;31(11):2148-53 - PubMed
    1. N Engl J Med. 1993 Sep 30;329(14):977-86 - PubMed