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. 2014 Jun 25:3:137.
doi: 10.4103/2277-9175.135154. eCollection 2014.

Serum level of substance P in patients with lung injuries due to sulfur mustard

Bita Najafian  1 , Majid Shohrati  2 , Ali Amini Harandi  3 , Shiva Mahyar  4 , Isa Khaheshi  2 , Mostafa Ghanei  2
Affiliations

Serum level of substance P in patients with lung injuries due to sulfur mustard

Bita Najafian et al. Adv Biomed Res. .

Abstract

Background: Chronic bronchiolitis is the most important problems of chemical victims of mustard gas. Diverse studies suggest that substance P (SP) as a member of tachykinin neuropeptides, has a significant role in the neurogenic inflammation processes of the airways and lungs. We aimed to determine the serum level of SP in chemical victims of mustard gas and compare it with normal subjects.

Materials and methods: The chemical victims were divided into the 2 groups of 30:A group with mild to moderate pulmonary symptoms and other group with moderate to severe symptoms and compared with 3(rd) group as healthy controls. After preparing our samples and using the SP kit, final analysis was performed with enzyme-linked immunosorbent assay reader.

Results: The Concentration of circulatory SP levels in the chemical patients was 2.86 ± 1.47 ng/ml and had not a significant difference with the control group (3.15 ± 1.03 ng/ml) (P > 0.05). The circulatory SP levels were 2.48 ± 0.92 ng/ml and 3.28 ± 1.73 ng/ml in patients with moderate to severe symptoms and mild to moderates (P < 0.05) respectively.

Conclusion: The SP may have a role in pulmonary complications of mustard gas. The lower level of SP in the moderate to severe patients may be due to corticosteroid consumption in such severe cases. However, further studies are needed to clarify the roles and mechanism of SP in this setting.

Keywords: Lung injuries; substance P; sulfur mustard.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
The serum levels of substance P in chemical exposed patients and healthy subjects
Figure 2
Figure 2
The circulatory levels of substance P in the mild to moderate, moderate to severe patients and control group
See this image and copyright information in PMC

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