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. 2014 Nov 1;180(9):901-8.
doi: 10.1093/aje/kwu195. Epub 2014 Aug 24.

Erythrocyte superoxide dismutase, glutathione peroxidase, and catalase activities and risk of coronary heart disease in generally healthy women: a prospective study

Shuman Yang, Majken K Jensen, Eric B Rimm, Walter Willett, Tianying Wu

Erythrocyte superoxide dismutase, glutathione peroxidase, and catalase activities and risk of coronary heart disease in generally healthy women: a prospective study

Shuman Yang et al. Am J Epidemiol. .

Abstract

Erythrocyte antioxidant enzymes are major circulating antioxidant enzymes in the oxidative stress defense system. Few prospective studies have assessed the association between these enzymes and the risk of coronary heart disease (CHD) in generally healthy adults. We conducted a prospective nested case-control study of CHD among 32,826 women at baseline with 15 years of follow-up from 1989 to 2004 in the Nurses' Health Study. We investigated the association of baseline erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities with the risk of CHD. A total of 365 cases and 728 controls were included in the analysis. Overall, the relative risks of CHD associated with 1-standard deviation higher SOD, GPx, and CAT activities were 1.07 (95% confidence interval (CI): 0.94, 1.22), 1.04 (95% CI: 0.91, 1.18), and 1.04 (95% CI: 0.92, 1.17), respectively. Multivariable adjustments did not change the associations appreciably. Fasting status did not modify the associations, with the exception that SOD activity was positively associated with the risk of CHD among participants who provided blood samples within 12 hours of fasting. Overall, activities of SOD, GPx, and CAT were not associated with CHD among women who were generally healthy at the time of blood collection.

Keywords: antioxidant enzymes; catalase; coronary heart disease; glutathione peroxidase; superoxide dismutase.

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Figures

Figure 1.
Figure 1.
Association between superoxide dismutase activity (per 1–standard deviation increase) and coronary heart disease, stratified by fasting duration in the Nurses’ Health Study, 1989–2004. The relative risk (RR) subtotals were adjusted for age, smoking, time and month of blood collection, body mass index (weight (kg)/height (m)2), physical activity, alcohol intake, menopausal status, family history of myocardial infarction, history of diabetes, history of hypertension, hormone replacement therapy, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and C-reactive protein. Squares represent point estimates of relative risk. Diamonds represent subtotal point estimates of relative risk. Bars, 95% confidence intervals (CIs).
Figure 2.
Figure 2.
Association between glutathione peroxidase activity (per 1–standard deviation increase) and coronary heart disease, stratified by fasting duration in the Nurses’ Health Study, 1989–2004. The relative risk (RR) subtotals were adjusted for age, smoking, time and month of blood collection, body mass index (weight (kg)/height (m)2), physical activity, alcohol intake, menopausal status, family history of myocardial infarction, history of diabetes, history of hypertension, hormone replacement therapy, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and C-reactive protein. Bars, 95% confidence intervals (CIs).
Figure 3.
Figure 3.
Association between catalase activity (per 1–standard deviation increase) and coronary heart disease, stratified by fasting duration in the Nurses’ Health Study, 1989–2004. The relative risk (RR) subtotals were adjusted for age, smoking, time and month of blood collection, body mass index (weight (kg)/height (m)2), physical activity, alcohol intake, menopausal status, family history of myocardial infarction, history of diabetes, history of hypertension, hormone replacement therapy, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and C-reactive protein. Squares represent point estimates of relative risk. Diamonds represent subtotal point estimates of relative risk. Bars, 95% confidence intervals (CIs).
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References

    1. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem. 1997;27234:20963–20966 - PubMed
    1. Ross R, Glomset JA. The pathogenesis of atherosclerosis. N Engl J Med. 1976;2957:369–377 - PubMed
    1. Stocker R, Keaney JF, Jr. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004;844:1381–1478 - PubMed
    1. Quinn MT, Parthasarathy S, Fong LG, et al. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci U S A. 1987;849:2995–2998 - PMC - PubMed
    1. Wu T, Rifai N, Willett WC, et al. Plasma fluorescent oxidation products: independent predictors of coronary heart disease in men. Am J Epidemiol. 2007;1665:544–551 - PubMed

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