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. 2014 Sep;19(3):323-8.
doi: 10.1517/14728214.2014.953052. Epub 2014 Aug 24.

Is there a need for emerging drugs for the acute respiratory distress syndrome?

Marianne Fitzgerald  1 , Daniel F McAuley, Michael Matthay
Affiliations

Is there a need for emerging drugs for the acute respiratory distress syndrome?

Marianne Fitzgerald et al. Expert Opin Emerg Drugs. 2014 Sep.

Abstract

The acute respiratory distress syndrome (ARDS) is a common and devastating syndrome of acute respiratory failure for which little effective pharmacotherapy exists. The authors describe some interventions that show promise as potential therapies for this condition, with particular reference to clinically relevant human models of ARDS. Aspirin, mesenchymal stromal (stem) cells, keratinocyte growth factor, IFN-β and oncostatin M inhibition are discussed.

Keywords: IFN-β; acute respiratory distress syndrome; aspirin; mesenchymal stromal cells; oncostatin M.

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Conflict of interest statement

Declaration of interest

M Fitzgerald receives funding from the Belfast Health and Social Care Trust Research and Development Office, as well as the Intensive Care Society of Ireland. DF McAuley has undertaken paid consultancy work and has been a member of advisory boards on ARDS for GlaxoSmithKline. This author’s institution has been paid for the author to undertake bronchosocopy as part of a clinical trial funded by GlaxoSmithKline. DF McAuley has a patent submitted for a novel treatment for ARDS, and is the chief investigator of a multi-center study investigating simvastatin as a therapy for ARDS (funded by the National Institute for Health and Research), chief investigator of a single center study investigating aspirin in ARDS (funded by the Northern Ireland Research and Development Office) and chief investigator of a single center study investigating aspirin in a model of ARDS (ARENA, NCT01659307; funded by the UK Intensive Care Society). DF McAuley acknowledges funding from the Northern Ireland Public Health Agency Research and Development Division Translational Research Group for Critical Care. M Matthay acknowledges grant support (NHLBI R37 HL51856).

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References

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