Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Oct:27:339-47.
doi: 10.1016/j.meegid.2014.07.030. Epub 2014 Aug 7.

The genetic variability of glycoproteins among respiratory syncytial virus subtype A in China between 2009 and 2013

Luo Ren  1 , Qiuling Xia  1 , Qiuyan Xiao  1 , Lili Zhou  1 , Na Zang  1 , Xiaoru Long  1 , Xiaohong Xie  2 , Yu Deng  2 , Lijia Wang  1 , Zhou Fu  2 , Daiyin Tian  2 , Yao Zhao  1 , Xiaodong Zhao  1 , Tingyu Li  1 , Ailong Huang  3 , Enmei Liu  4
Affiliations

The genetic variability of glycoproteins among respiratory syncytial virus subtype A in China between 2009 and 2013

Luo Ren et al. Infect Genet Evol. 2014 Oct.

Abstract

Human respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in infants and children under 5years of age. The novel genotype ON1 has a 72-nucleotide duplication, which is the largest duplicated genome portion of RSV. Whether the ON1 genotype will follow the pattern of the BA genotype, which has a 60-nucleotide duplication, and become the predominant RSV-A strain is a global concern. To obtain information regarding the prevalence of the ON1 genotype in Chongqing in Southwestern China, we examined the circulation pattern of RSV-A identified over four consecutive years (June 2009 to August 2013). In this study, 312 (12%) RSV-A strains were isolated from 2601 nasopharyngeal aspirates, and partial G gene was sequenced successfully in 250 isolates. Of the sequenced Chongqing RSV-A isolates, 237 (94.8%) strains were the NA1 genotype, 4 (1.6%) strains were the NA3 genotype, 4 (1.6%) strains were the NA4 genotype, 1 (0.4%) strain was the GA1 genotype, and 4 (1.6%) strains were identified as the ON1 genotype. Analysis of the distribution, phylogeny, and evolution of the ON1 strains that were collected globally until December 2013 revealed that the ON1 genotype has rapidly disseminated across the world under positive selection pressures. Future studies will determine whether this new genotype will continue to spread and become the dominant strain of RSV-A worldwide. These findings may contribute to the understanding of RSV evolution and to the potential development of a vaccine against RSV.

Keywords: G glycoprotein; ON1; Respiratory syncytial virus.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Substances

Associated data

LinkOut - more resources